Metadate cd and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metadate cd (methylphenidate hydrochloride) and Zoloft (sertraline hydrochloride). Common drug interactions include head injury among females and dystonia among males.

The phase IV clinical study analyzes what interactions people have when they take Metadate cd and Zoloft. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Metadate cd?

Metadate cd has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 646 Metadate cd users. Check the latest studies of Metadate cd.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

On Jul, 12, 2026

14 people who take Metadate cd and Zoloft together, and have interactions are studied.

Metadate cd and Zoloft drug interactions.

What are the common drug interactions of Metadate Cd and Zoloft, by gender? *:

female:

Head injury
Muscle spasms (muscle contraction)
Aphasia (damage to the parts of the brain that control language)
Decreased appetite
Dysgraphia (impaired ability to learn to write)
Hypoaesthesia (reduced sense of touch or sensation)
Muscle twitching
Poor quality sleep
Tinnitus (a ringing in the ears)
Aggression

male:

Dystonia (abnormal muscle tone)
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)

What are the common drug interactions of Metadate Cd and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Suicidal ideation

20-29:

Aggression
Crying
Dizziness
Hypersomnia (excessive daytime sleepiness (eds))
Memory impairment
Mood swings (an extreme or rapid change in mood)
Muscle spasms (muscle contraction)
Screaming (a long loud piercing cry)

30-39:

n/a

40-49:

Aphasia (damage to the parts of the brain that control language)
Decreased appetite
Dysgraphia (impaired ability to learn to write)
Hypoaesthesia (reduced sense of touch or sensation)
Muscle spasms (muscle contraction)
Muscle twitching
Poor quality sleep
Tinnitus (a ringing in the ears)
Nerve compression

50-59:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Metabolic syndrome (a combination of the medical disorders that, when occurring together, increase the risk of developing cardiovascular disease)
Type 2 diabetes mellitus

60+:

Ammonia increased
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Nausea (feeling of having an urge to vomit)
Sinusitis (inflammation of sinus)
Wrist fracture

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 64.29%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 42.86%
Stress And Anxiety: 2 people, 14.29%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 14.29%
Sleep Paralysis (waking up and unable to move or speak): 1 person, 7.14%
Poor Quality Sleep: 1 person, 7.14%
Panic Disorder: 1 person, 7.14%
Muscle Spasms (muscle contraction): 1 person, 7.14%
Mood Swings (an extreme or rapid change in mood): 1 person, 7.14%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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