Metaxalone and Opsumit drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metaxalone (metaxalone) and Opsumit (macitentan). Common drug interactions include dyspnoea among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Metaxalone and Opsumit. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Metaxalone?

Metaxalone has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 4,452 Metaxalone users. Check the latest studies of Metaxalone.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

On Jul, 14, 2026

19 people who take Metaxalone and Opsumit together, and have interactions are studied.

Metaxalone and Opsumit drug interactions.

What are the common drug interactions of Metaxalone and Opsumit, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Blood creatinine increased
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Dizziness
Dry skin
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Enterococcal infection
Erythema (redness of the skin)

male:

Dyspnoea (difficult or laboured respiration)
Blood potassium increased
Tremor (trembling or shaking movements in one or more parts of your body)
Blood glucose decreased
Drug ineffective
Dyspnoea exertional (breathlessness or shortness of breath)
Fluid retention (an abnormal accumulation of fluid in the blood)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Peripheral swelling
Right ventricular failure (right half of the heart fails to work)

What are the common drug interactions of Metaxalone and Opsumit, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Blood creatinine increased
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Dizziness
Dry skin
Dyspnoea (difficult or laboured respiration)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Enterococcal infection
Erythema (redness of the skin)

50-59:

Cardiac failure congestive
Dyspnoea (difficult or laboured respiration)
Influenza like illness
Spinal compression fracture (fracture due to spinal compression on bone)
Upper respiratory tract infection

60+:

Dyspnoea (difficult or laboured respiration)
Haemoglobin decreased
Head injury
Muscular weakness (muscle weakness)
Reflux gastritis (a condition in which the lining of a person's stomach becomes inflamed as a result of exposure to bile)
Renal failure (kidney dysfunction)
Syncope (loss of consciousness with an inability to maintain postural tone)
Anaemia (lack of blood)
Respiratory tract infection
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 15 people, 78.95%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 10.53%
Essential Hypertension (primary hypertension): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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