Metformin hydrochloride and Eylea drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin hydrochloride (metformin hydrochloride) and Eylea (aflibercept). Common drug interactions include visual acuity reduced among females and visual acuity reduced among males.

The phase IV clinical study analyzes what interactions people have when they take Metformin hydrochloride and Eylea. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Metformin hydrochloride?

Metformin hydrochloride has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 58,646 Metformin hydrochloride users. Check the latest studies of Metformin hydrochloride.

What is Eylea?

Eylea has active ingredients of aflibercept. It is often used in macular degeneration. eHealthMe is studying from 27,868 Eylea users. Check the latest studies of Eylea.

On Jul, 14, 2026

45 people who take Metformin hydrochloride and Eylea together, and have interactions are studied.

Metformin hydrochloride and Eylea drug interactions.

What are the common drug interactions of Metformin Hydrochloride and Eylea, by gender? *:

female:

Visual acuity reduced (reduced clearness of vision)
Blindness unilateral
Eye pain
Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Vitreous opacities (vitreous opacities generally develop as aging changes within the eye)
Blood glucose increased
Cataract (clouding of the lens inside the eye)
Cataract cortical (it affects outer part of lens)
Conjunctival haemorrhage (bleeding underneath the conjunctiva)
Crying

male:

Visual acuity reduced (reduced clearness of vision)
Blood pressure increased
Endophthalmitis (inflammation of the internal coats of the eye)
Eye pain
Intraocular pressure increased
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Ocular hypertension (intraocular pressure higher than normal)
Pulmonary mass
Visual impairment
Hyphaema (collection of blood inside the front part of the eye)

What are the common drug interactions of Metformin Hydrochloride and Eylea, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Lactic acidosis (low ph in body tissues)

50-59:

Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Blood glucose increased
Cataract (clouding of the lens inside the eye)
Cataract cortical (it affects outer part of lens)
Crying
Eye irritation
Eye pruritus (eye itching)
Metamorphopsia (a type of distorted vision in which a grid of straight lines appears wavy and parts of the grid may appear blank)
Visual acuity reduced (reduced clearness of vision)

60+:

Visual acuity reduced (reduced clearness of vision)
Vitreous haemorrhage (intraocular (inside the eye) bleeding)
Intraocular pressure increased
Uveitis (inflammation of the uvea)
Pyrexia (fever)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Blindness transient (sudden loss of vision)
Blood pressure increased
Cerebral haemorrhage (bleeding within the brain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the existing conditions these people have? *

Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 21 people, 46.67%
Type 2 Diabetes: 13 people, 28.89%
High Blood Cholesterol: 8 people, 17.78%
High Blood Pressure: 7 people, 15.56%
Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 7 people, 15.56%
Macular Oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken): 6 people, 13.33%
Hypersensitivity: 3 people, 6.67%
Age-Related Macular Degeneration: 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin hydrochloride and Eylea?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously