Metformin and Acalabrutinib drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin (metformin hydrochloride) and Acalabrutinib (acalabrutinib). Common drug interactions include nausea among females and hyponatraemia among males.

The phase IV clinical study analyzes what interactions people have when they take Metformin and Acalabrutinib. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Acalabrutinib?

Acalabrutinib has active ingredients of acalabrutinib. eHealthMe is studying from 1,237 Acalabrutinib users. Check the latest studies of Acalabrutinib.

On May, 05, 2026

46 people who take Metformin and Acalabrutinib together, and have interactions are studied.

Metformin and Acalabrutinib drug interactions.

What are the common drug interactions of Metformin and Acalabrutinib, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Syncope (loss of consciousness with an inability to maintain postural tone)
Vomiting
Colitis (inflammation of colon)
Dehydration (dryness resulting from the removal of water)
Urinary tract infection
Pseudomonal bacteraemia (p. aeruginosa cause of bacterial infections of the blood)
Urinary tract infection bacterial
Febrile neutropenia (fever with reduced white blood cells)
Pneumonia

male:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Thyroid cancer
Flushing (the warm, red condition of human skin)
Pyrexia (fever)
Facial nerve disorder (disease of face nerve)
Anaemia macrocytic (a macrocytic class of anaemia)
Atrioventricular block first degree (heart block first degree)
Balance disorder
Dizziness
Epistaxis (bleed from the nose)

What are the common drug interactions of Metformin and Acalabrutinib, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Nausea (feeling of having an urge to vomit)
Syncope (loss of consciousness with an inability to maintain postural tone)
Urinary tract infection bacterial
Febrile neutropenia (fever with reduced white blood cells)
Multiple system atrophy (degeneration of nerve cells in specific areas of the brain)
Pneumonia
Bacterial sepsis
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Prostate cancer
Alanine aminotransferase increased

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 24 people, 52.17%
High Blood Pressure: 17 people, 36.96%
Pain: 13 people, 28.26%
Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 12 people, 26.09%
Type 2 Diabetes: 11 people, 23.91%
Insomnia (sleeplessness): 11 people, 23.91%
Diarrhea: 9 people, 19.57%
Hyperlipidaemia (presence of excess lipids in the blood): 9 people, 19.57%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 9 people, 19.57%
Urinary Tract Infection: 8 people, 17.39%

* Approximation only. Some reports may have incomplete information.

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