Metformin and Brivaracetam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin (metformin hydrochloride) and Brivaracetam (brivaracetam). Common drug interactions include seizure among females and seizure among males.

The phase IV clinical study analyzes what interactions people have when they take Metformin and Brivaracetam. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Brivaracetam?

Brivaracetam has active ingredients of brivaracetam. eHealthMe is studying from 3,319 Brivaracetam users. Check the latest studies of Brivaracetam.

On Jul, 17, 2026

35 people who take Metformin and Brivaracetam together, and have interactions are studied.

Metformin and Brivaracetam drug interactions.

What are the common drug interactions of Metformin and Brivaracetam, by gender? *:

female:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Fall
Malaise (a feeling of general discomfort or uneasiness)
Cough
Facial paralysis (loss of function of face muscle)
Immunodeficiency
Nervousness
Restlessness (not able to rest)
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)

male:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Ankle fracture
Sleep disorder
Weight increased
Head discomfort
Oedema (fluid collection in tissue)
Oesophageal disorder (disease of oesophagus)
Spinal cord disorder (disease of spinal cord)
Bradycardia (abnormally slow heart action)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

What are the common drug interactions of Metformin and Brivaracetam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Sudden unexplained death in epilepsy
Fall
Psoriasis (immune-mediated disease that affects the skin)
Weight increased

30-39:

n/a

40-49:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Back pain
Fall
Fatigue (feeling of tiredness)
Gallbladder enlargement
Hepatic failure (liver failure)
Hyperthyroidism (over activity of the thyroid gland)
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)

50-59:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Malaise (a feeling of general discomfort or uneasiness)
Cough
Facial paralysis (loss of function of face muscle)
Immunodeficiency
Nervousness
Restlessness (not able to rest)
Dry mouth
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Loss of consciousness

60+:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Bradycardia (abnormally slow heart action)
Somnolence (a state of near-sleep, a strong desire for sleep)
Drug ineffective
Emotional disorder
Death
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hypoaesthesia (reduced sense of touch or sensation)
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Cardiac arrest

What are the existing conditions these people have? *

Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 15 people, 42.86%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 9 people, 25.71%
High Blood Pressure: 8 people, 22.86%
Depression: 7 people, 20.00%
High Blood Cholesterol: 6 people, 17.14%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 17.14%
Partial Seizures (seizures which affect only a part of the brain at onset): 4 people, 11.43%
Stable Angina (a constant chest pain): 3 people, 8.57%
Rickets (softening of bones): 3 people, 8.57%
Back Pain: 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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