Metformin and Bromocriptine mesylate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin (metformin hydrochloride) and Bromocriptine mesylate (bromocriptine mesylate). Common drug interactions include arthralgia among females and syncope among males.

The phase IV clinical study analyzes what interactions people have when they take Metformin and Bromocriptine mesylate. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

What is Bromocriptine mesylate?

Bromocriptine mesylate has active ingredients of bromocriptine mesylate. It is often used in prolactinoma. eHealthMe is studying from 1,011 Bromocriptine mesylate users. Check the latest studies of Bromocriptine mesylate.



On Aug, 11, 2026

27 people who take Metformin and Bromocriptine mesylate together, and have interactions are studied.

Metformin and Bromocriptine mesylate drug interactions.

What are the common drug interactions of Metformin and Bromocriptine Mesylate, by gender? *:

female:

  1. Arthralgia (joint pain)
  2. Lethargy (tiredness)
  3. Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
  4. Anxiety
  5. Crying
  6. Dysphonia (speech disorder attributable to a disorder of phonation)
  7. Dyspnoea (difficult or laboured respiration)
  8. Eye disorder
  9. Face oedema (swelling of face)
  10. Malaise (a feeling of general discomfort or uneasiness)

male:

  1. Syncope (loss of consciousness with an inability to maintain postural tone)
  2. Sepsis (a severe blood infection that can lead to organ failure and death)
  3. Abscess jaw (tooth abscess or root abscess)
  4. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  5. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  6. Blood glucose decreased
  7. Calculus urinary (stone in urinary system)
  8. Fatigue (feeling of tiredness)
  9. Hypersensitivity
  10. Injection site mass

What are the common drug interactions of Metformin and Bromocriptine Mesylate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Somnambulism (sleep walking)
  2. Cellulitis (infection under the skin)
  3. Groin abscess (pus in groin)
  4. Leukocytosis (increased white blood cells)
  5. Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
  6. Perineal abscess
  7. Perirectal abscess
  8. Scrotal abscess (pus in scrotum)
  9. Sepsis (a severe blood infection that can lead to organ failure and death)
  10. Subcutaneous abscess

40-49:

  1. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  2. Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
  3. Pancreatitis acute (sudden inflammation of pancreas)

50-59:

  1. Arthralgia (joint pain)
  2. Lethargy (tiredness)
  3. Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
  4. Pituitary tumour benign
  5. Erythema of eyelid (redness of the eyelid)
  6. Eye pain
  7. Eye swelling
  8. Eyelid pain
  9. Headache (pain in head)
  10. Lacrimation increased

60+:

  1. Syncope (loss of consciousness with an inability to maintain postural tone)
  2. Abscess jaw (tooth abscess or root abscess)
  3. Hypersensitivity
  4. Injection site mass
  5. Melaena (the passage of black, tarry stools)
  6. Myalgia (muscle pain)
  7. Pyrexia (fever)
  8. Rash generalised (rash on most of body parts)
  9. Sepsis (a severe blood infection that can lead to organ failure and death)
  10. Tooth extraction

What are the existing conditions these people have? *

  1. Ill-Defined Disorder: 6 people, 22.22%
  2. Type 2 Diabetes: 4 people, 14.81%
  3. Depression: 4 people, 14.81%
  4. Acromegaly (body produces too much growth hormone, leading to excess growth of body tissues): 4 people, 14.81%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Metformin and Bromocriptine mesylate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Bromocriptine mesylate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Metformin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Bromocriptine mesylate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride and bromocriptine mesylate (the active ingredients of Metformin and Bromocriptine mesylate, respectively), and Metformin and Bromocriptine mesylate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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