Metformin and Cotellic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin (metformin hydrochloride) and Cotellic (cobimetinib fumarate). Common drug interactions include chest pain among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Metformin and Cotellic. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Cotellic?

Cotellic has active ingredients of cobimetinib fumarate. eHealthMe is studying from 1,908 Cotellic users. Check the latest studies of Cotellic.

On Jul, 09, 2026

27 people who take Metformin and Cotellic together, and have interactions are studied.

Metformin and Cotellic drug interactions.

What are the common drug interactions of Metformin and Cotellic, by gender? *:

female:

Chest pain
Erythema (redness of the skin)
Pruritus (severe itching of the skin)
Extravasation blood (leakage of blood from a vessel into tissues)
Haemoglobin decreased
Haemorrhage subcutaneous (bleeding from skin)
Pancreatitis acute (sudden inflammation of pancreas)

male:

Diarrhoea
Asthenia (weakness)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Blood creatine phosphokinase increased
Interstitial lung disease
Myocarditis (inflammation of heart muscle myocardium)
Neurological decompensation (inability of brain to maintain proper function)
Ammonia increased
Balance disorder
Dizziness

What are the common drug interactions of Metformin and Cotellic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood creatine phosphokinase increased
Interstitial lung disease
Myocarditis (inflammation of heart muscle myocardium)
Neurological decompensation (inability of brain to maintain proper function)
Oedema peripheral (superficial swelling)

40-49:

n/a

50-59:

Chest pain
Erythema (redness of the skin)
Pruritus (severe itching of the skin)
Cholestatic liver injury (due to injury bile cannot floe from liver)
Diarrhoea
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypersensitivity
Lactic acidosis (low ph in body tissues)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Oedema peripheral (superficial swelling)

60+:

Diarrhoea
Asthenia (weakness)
Ammonia increased
Balance disorder
Dizziness
Metastases to central nervous system (cancer spreads to central nervous system)
Oral pain
Arrhythmia (irregular heartbeat)
Death
Duodenal ulcer

What are the existing conditions these people have? *

Malignant Melanoma (skin cancer rises from melancytes): 14 people, 51.85%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 10 people, 37.04%
Type 2 Diabetes: 4 people, 14.81%
Malignant Melanoma Stage Iv (the cancer has spread to other places in the body, such as the lung, liver, brain, bone, soft tissue, or gastrointestinal (gi) tract. cancer may have spread to places in the skin far away from where it first started): 4 people, 14.81%
High Blood Pressure: 4 people, 14.81%
Hyperglycemia (high blood sugar): 3 people, 11.11%
Enlarged Prostate: 3 people, 11.11%
Skin Cancer: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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