Metformin and Elidel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin (metformin hydrochloride) and Elidel (pimecrolimus). Common drug interactions include anxiety among females and pruritus among males.

The phase IV clinical study analyzes what interactions people have when they take Metformin and Elidel. It is created by eHealthMe based on reports of 93 people who take the same drugs from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

What is Elidel?

Elidel has active ingredients of pimecrolimus. It is often used in eczema. eHealthMe is studying from 5,201 Elidel users. Check the latest studies of Elidel.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

93 people who take Metformin and Elidel together, and have interactions are studied.

What are the common drug interactions of Metformin and Elidel, by gender? *:

female:

Anxiety
Chest pain
Urticaria (rash of round, red welts on the skin that itch intensely)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Decreased appetite
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Eye swelling
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Pain in extremity

male:

Pruritus (severe itching of the skin)
Psoriasis (immune-mediated disease that affects the skin)
Pneumonia
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Arthralgia (joint pain)
Blood glucose increased
Diarrhoea
Fungal infection
Hypoaesthesia (reduced sense of touch or sensation)
Neuropathy peripheral (surface nerve damage)

What are the common drug interactions of Metformin and Elidel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Acne (skin problems that cause pimples)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Chronic kidney disease
Cough
Emotional distress
Pain
Rash erythematous (redness of the skin)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Drug effect decreased
Dyspnoea (difficult or laboured respiration)
Injury
Pain
Paranasal sinus discomfort
Pulmonary embolism (blockage of the main artery of the lung)
Seasonal allergy (allergic condition due to certain season)
Sinus congestion (blockage of sinus)

50-59:

Dehydration (dryness resulting from the removal of water)
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Epistaxis (bleed from the nose)
Flushing (the warm, red condition of human skin)
Gastritis (inflammation of stomach)
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Hyperkalaemia (damage to or disease of the kidney)
Hypoaesthesia (reduced sense of touch or sensation)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Urticaria (rash of round, red welts on the skin that itch intensely)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Drug ineffective
Nasopharyngitis (inflammation of the nasopharynx)
Nephrogenic anaemia (anaemia due to kidney disease)
Pain in extremity
Viral infection
Abasia (inability to walk)

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 21 people, 22.58%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 12 people, 12.90%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 12 people, 12.90%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 12.90%
High Blood Pressure: 12 people, 12.90%
Pain: 11 people, 11.83%
Stress And Anxiety: 11 people, 11.83%
Depression: 9 people, 9.68%
Itching: 8 people, 8.60%
High Blood Cholesterol: 8 people, 8.60%

* Approximation only. Some reports may have incomplete information.

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