Metformin and Evening primrose oil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin (metformin hydrochloride) and Evening primrose oil (evening primrose oil). Common drug interactions include nausea among females and c-reactive protein increased among males.

The phase IV clinical study analyzes what interactions people have when they take Metformin and Evening primrose oil. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Evening primrose oil?

Evening primrose oil has active ingredients of evening primrose oil. It is often used in premenstrual syndrome. eHealthMe is studying from 1,392 Evening primrose oil users. Check the latest studies of Evening primrose oil.

On Jul, 17, 2026

73 people who take Metformin and Evening primrose oil together, and have interactions are studied.

Metformin and Evening primrose oil drug interactions.

What are the common drug interactions of Metformin and Evening Primrose Oil, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Neoplasm progression (growth of tumour)
Peripheral swelling
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Poor quality sleep
Urticaria (rash of round, red welts on the skin that itch intensely)
White blood cell count decreased
Abasia (inability to walk)
Abnormal behaviour
Anxiety

male:

C-reactive protein increased
Body temperature decreased
Pain
Platelet count decreased
Pyrexia (fever)
Toothache (tooth pain)
Arthralgia (joint pain)
Blood cholesterol increased
Blood glucose increased
Blood triglycerides increased

What are the common drug interactions of Metformin and Evening Primrose Oil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Blood magnesium decreased
Dehydration (dryness resulting from the removal of water)
Disturbance in attention
Drug ineffective
Drug screen false positive
Drug screen positive
Haematemesis (vomiting of blood)
Muscle spasms (muscle contraction)
Vomiting

40-49:

Alanine aminotransferase increased
Angioedema (rapid swelling of the dermis)
Aspartate aminotransferase increased
Erythema (redness of the skin)
Gamma-glutamyltransferase increased
Hepatic enzyme increased
Hepatic steatosis (fatty liver disease)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Urticaria (rash of round, red welts on the skin that itch intensely)
Anaemia (lack of blood)

50-59:

Toothache (tooth pain)
Arthralgia (joint pain)
Blood glucose increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Diabetes mellitus inadequate control
Flushing (the warm, red condition of human skin)
Hypertension (high blood pressure)
Inflammation
Injection site pruritus (severe itching at injection site)
Joint swelling

60+:

Headache (pain in head)
Cough
Arthralgia (joint pain)
Body height increased
Fall
Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Muscle spasms (muscle contraction)
Pain in extremity
Blood potassium decreased

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 10.96%
High Blood Pressure: 8 people, 10.96%
High Blood Cholesterol: 8 people, 10.96%
Type 2 Diabetes: 6 people, 8.22%
Neuropathy Peripheral (surface nerve damage): 6 people, 8.22%
Pain: 5 people, 6.85%
Neuralgia (pain in one or more nerves): 5 people, 6.85%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 6.85%
Hypoaesthesia (reduced sense of touch or sensation): 5 people, 6.85%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 5.48%

* Approximation only. Some reports may have incomplete information.

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