Metformin and Mifepristone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin (metformin hydrochloride) and Mifepristone (mifepristone). Common drug interactions include formication among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Metformin and Mifepristone. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Mifepristone?

Mifepristone has active ingredients of mifepristone. eHealthMe is studying from 3,112 Mifepristone users. Check the latest studies of Mifepristone.

On Jul, 11, 2026

42 people who take Metformin and Mifepristone together, and have interactions are studied.

Metformin and Mifepristone drug interactions.

What are the common drug interactions of Metformin and Mifepristone, by gender? *:

female:

Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Hallucination (an experience involving the perception of something not present)
Hypersomnia (excessive daytime sleepiness (eds))
Rash
Somnolence (a state of near-sleep, a strong desire for sleep)
Vaginal haemorrhage (vaginal bleeding)
Anaemia (lack of blood)
Anxiety
Back pain
Chest pain

male:

Nausea (feeling of having an urge to vomit)
Blood glucose increased
Blood potassium decreased
Constipation
Pain in extremity
Blood sodium decreased
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Feeling jittery
Peripheral swelling
Weight increased

What are the common drug interactions of Metformin and Mifepristone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Haemorrhage (bleeding)
Palpable purpura (purple or brownish-red spots on the skin or mucous)
Vasculitis (inflammation of a blood vessel or blood vessels)

30-39:

Blood glucose decreased
Drug resistance (reduction in effectiveness of a drug)
Blood glucose increased
Constipation
Fatigue (feeling of tiredness)
Headache (pain in head)
Hyperthyroidism (over activity of the thyroid gland)
Nausea (feeling of having an urge to vomit)
Presyncope
Tremor (trembling or shaking movements in one or more parts of your body)

40-49:

Dizziness
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Anaemia (lack of blood)
Haematuria (presence of blood in urine)
Nephrolithiasis (calculi in the kidneys)
Arthralgia (joint pain)
Blood glucose increased
Blood pressure increased
Blood thyroid stimulating hormone decreased

50-59:

Dizziness
Headache (pain in head)
Constipation
Arthralgia (joint pain)
Vomiting
Dyspnoea (difficult or laboured respiration)
Feeling jittery
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Peripheral swelling

60+:

Blood pressure increased
Dizziness
Pain in extremity
Swelling
Hypoglycaemia (deficiency of glucose in the bloodstream)
Oedema peripheral (superficial swelling)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry eye (lack of adequate tears)
Eye irritation

What are the existing conditions these people have? *

Cushing's Syndrome (obesity, a rounded face, increased fat): 36 people, 85.71%
Type 2 Diabetes: 6 people, 14.29%
High Blood Pressure: 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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