Metformin and Polytrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin (metformin hydrochloride) and Polytrim (polymyxin b sulfate; trimethoprim sulfate). Common drug interactions include dysmenorrhoea among females and conjunctival bleb among males.

The phase IV clinical study analyzes what interactions people have when they take Metformin and Polytrim. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Polytrim?

Polytrim has active ingredients of polymyxin b sulfate; trimethoprim sulfate. eHealthMe is studying from 376 Polytrim users. Check the latest studies of Polytrim.

On Jul, 28, 2026

48 people who take Metformin and Polytrim together, and have interactions are studied.

Metformin and Polytrim drug interactions.

What are the common drug interactions of Metformin and Polytrim, by gender? *:

female:

Dysmenorrhoea (painful menstruation)
Eye infection
Eye pain
Eye swelling
Eyelid function disorder
Fatigue (feeling of tiredness)
Foreign body sensation in eyes (feeling of something in eye)
Gastritis (inflammation of stomach)
Haemorrhage (bleeding)
Hyperhidrosis (abnormally increased sweating)

male:

Conjunctival bleb (blister of eye covering)
Cataract subcapsular (cataracts that affect the back of the lens)
Macular fibrosis (a thin sheet of scar tissue forms on top of the macula, in response to damage or injury)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Retinal oedema (swelling of retina)
Retinal pigmentation (pigmentation of retina)
Vision blurred
Visual acuity reduced (reduced clearness of vision)
Vitreous detachment (a condition of the eye in which the vitreous humour separates from the retina)
Anaemia (lack of blood)

What are the common drug interactions of Metformin and Polytrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Somnolence (a state of near-sleep, a strong desire for sleep)
Therapeutic response unexpected
Weight decreased
Abdominal pain upper
Back pain
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood pressure increased
Chest pain
Decreased appetite
Drug ineffective

40-49:

Blood glucose increased
Chorioretinal scar (an area of pigmentary change in eye)
Conjunctival hyperaemia (congestion of conjunctival vessels)
Conjunctivitis allergic (inflammation of the conjunctiva due to allergy)
Cystoid macular oedema (fluid accumulation after cataract surgery)
Eye inflammation
Glaucoma (increased fluid pressure in the eye with vision loss)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Metamorphopsia (a type of distorted vision in which a grid of straight lines appears wavy and parts of the grid may appear blank)
Photopsia (presence of perceived flashes of light)

50-59:

Conjunctival bleb (blister of eye covering)
Cataract subcapsular (cataracts that affect the back of the lens)
Death

60+:

Renal failure (kidney dysfunction)
Arthralgia (joint pain)
Dry mouth
Dry skin
Dysstasia (difficulty in standing)
Fall
Glaucoma (increased fluid pressure in the eye with vision loss)
Hypokinesia (decreased bodily movement)
Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

What are the existing conditions these people have? *

Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 19 people, 39.58%
High Blood Cholesterol: 17 people, 35.42%
High Blood Pressure: 15 people, 31.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 20.83%
Uveitis (inflammation of the uvea): 8 people, 16.67%
Type 2 Diabetes: 5 people, 10.42%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 10.42%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 10.42%
Corneal Oedema (corneal swelling): 5 people, 10.42%
Pain: 4 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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