Metformin and Previfem drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin (metformin hydrochloride) and Previfem (ethinyl estradiol; norgestimate). Common drug interactions include acute psychosis among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Metformin and Previfem. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

What is Previfem?

Previfem has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 602 Previfem users. Check the latest studies of Previfem.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

16 people who take Metformin and Previfem together, and have interactions are studied.

Metformin and Previfem drug interactions.

What are the common drug interactions of Metformin and Previfem, by gender? *:

female:

Acute psychosis (period of mentally unstable behaviour)
Anxiety
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Bipolar disorder (mood disorder)
Hypertension (high blood pressure)
Nasopharyngitis (inflammation of the nasopharynx)
Respiratory syncytial virus infection (viral disease of respiratory system)
Somnambulism (sleep walking)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea

male:

Abdominal pain
Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Colostomy
Diarrhoea
Gallbladder non-functioning

What are the common drug interactions of Metformin and Previfem, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Abdominal pain upper
Adnexa uteri pain
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Arthralgia (joint pain)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Chills (felling of cold)
Cholecystitis (infection of gallbladder)
Cystitis (inflammation of the wall of the bladder)
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)

20-29:

Abdominal pain
Abdominal pain upper
Acute psychosis (period of mentally unstable behaviour)
Anxiety
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Gallbladder non-functioning
Hypertension (high blood pressure)
Nasopharyngitis (inflammation of the nasopharynx)

30-39:

Chronic kidney disease
Mobility decreased (ability to move is reduced)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Pericardial effusion (fluid around the heart)
Pulmonary embolism (blockage of the main artery of the lung)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

40-49:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 50.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 37.50%
Asthma: 4 people, 25.00%
Excessive Or Unwanted Hair In Women: 3 people, 18.75%
Pain: 3 people, 18.75%
Insulin Resistance: 3 people, 18.75%
Drowsiness: 3 people, 18.75%
Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 2 people, 12.50%
Vaginal Infection: 1 person, 6.25%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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