Metformin and Quinapril hydrochloride and hydrochlorothiazide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin (metformin hydrochloride) and Quinapril hydrochloride and hydrochlorothiazide (hydrochlorothiazide; quinapril hydrochloride). Common drug interactions include asthenia among females and amnesia among males.

The phase IV clinical study analyzes what interactions people have when they take Metformin and Quinapril hydrochloride and hydrochlorothiazide. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Quinapril hydrochloride and hydrochlorothiazide?

Quinapril hydrochloride and hydrochlorothiazide has active ingredients of hydrochlorothiazide; quinapril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 62 Quinapril hydrochloride and hydrochlorothiazide users. Check the latest studies of Quinapril hydrochloride and hydrochlorothiazide.



On Jul, 12, 2026

12 people who take Metformin and Quinapril hydrochloride and hydrochlorothiazide together, and have interactions are studied.

Metformin and Quinapril hydrochloride and hydrochlorothiazide drug interactions.

What are the common drug interactions of Metformin and Quinapril Hydrochloride And Hydrochlorothiazide, by gender? *:

female:

  1. Asthenia (weakness)
  2. Cardiac failure
  3. Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  4. Nausea (feeling of having an urge to vomit)
  5. Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
  6. Chest pain
  7. Ear pain
  8. Headache (pain in head)
  9. Hepatitis (inflammation of the liver)
  10. Hyperkalaemia (damage to or disease of the kidney)

male:

  1. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  2. Blood cholesterol increased
  3. Hyperglycaemia (high blood sugar)
  4. Hyperlipidaemia (presence of excess lipids in the blood)
  5. Neuropathy peripheral (surface nerve damage)
  6. Parkinson's disease
  7. Agitation (state of anxiety or nervous excitement)
  8. Altered state of consciousness (altered state of mind)
  9. Sedation

What are the common drug interactions of Metformin and Quinapril Hydrochloride And Hydrochlorothiazide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Ear pain
  2. Hepatitis (inflammation of the liver)
  3. Pain
  4. Pancreatic disorder
  5. Sinus congestion (blockage of sinus)

60+:

  1. Arthralgia (joint pain)
  2. Asthenia (weakness)
  3. Neuropathy peripheral (surface nerve damage)
  4. Parkinson's disease
  5. Agitation (state of anxiety or nervous excitement)
  6. Altered state of consciousness (altered state of mind)
  7. Chest pain
  8. Headache (pain in head)
  9. Hyperkalaemia (damage to or disease of the kidney)
  10. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 25.00%
  2. Urinary Tract Infection: 2 people, 16.67%
  3. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 16.67%
  4. Pneumonia: 2 people, 16.67%
  5. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 16.67%
  6. Lipids Increased (excess lipid in body): 1 person, 8.33%
  7. Bipolar Disorder (mood disorder): 1 person, 8.33%
  8. Chest Pain: 1 person, 8.33%
  9. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 1 person, 8.33%
  10. Conjunctivitis (pink eye): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Metformin and Quinapril hydrochloride and hydrochlorothiazide:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

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Browse all side effects of Quinapril hydrochloride and hydrochlorothiazide:

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Browse all interactions between Metformin and drugs from A to Z:

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Browse all interactions between Quinapril hydrochloride and hydrochlorothiazide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride and hydrochlorothiazide; quinapril hydrochloride (the active ingredients of Metformin and Quinapril hydrochloride and hydrochlorothiazide, respectively), and Metformin and Quinapril hydrochloride and hydrochlorothiazide (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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