Metformin and Temodar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin (metformin hydrochloride) and Temodar (temozolomide). Common drug interactions include asthenia among females and cholelithiasis among males.

The phase IV clinical study analyzes what interactions people have when they take Metformin and Temodar. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Temodar?

Temodar has active ingredients of temozolomide. It is often used in glioblastoma multiforme. eHealthMe is studying from 6,683 Temodar users. Check the latest studies of Temodar.

On Jul, 14, 2026

67 people who take Metformin and Temodar together, and have interactions are studied.

Metformin and Temodar drug interactions.

What are the common drug interactions of Metformin and Temodar, by gender? *:

female:

Asthenia (weakness)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional distress
General physical health deterioration (weak health status)
Injury
Pancreatic carcinoma (pancreatic cancer)
Pulmonary embolism (blockage of the main artery of the lung)
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)

male:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Nausea (feeling of having an urge to vomit)
Large intestinal haemorrhage (bleeding in large intestine)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Rash
Acute myocardial infarction (acute heart attack)
Agitation (state of anxiety or nervous excitement)
Bile duct stone
Cellulitis (infection under the skin)
Coeliac disease (simple food intolerance)

What are the common drug interactions of Metformin and Temodar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Bone marrow failure
Confusional state
Death
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

30-39:

n/a

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Bile duct stone
Cellulitis (infection under the skin)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coeliac disease (simple food intolerance)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Duodenal polyp (duodenal epithelial tumours)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hepatic cyst
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)

50-59:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional distress
General physical health deterioration (weak health status)
Injury
Pain
Pancreatic carcinoma (pancreatic cancer)
Pulmonary embolism (blockage of the main artery of the lung)
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Erythema (redness of the skin)
Insomnia (sleeplessness)

60+:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Confusional state
Decreased appetite
Hyperbilirubinaemia (excess of bilirubin in the blood)
Neoplasm progression (growth of tumour)
Nephritis interstitial (a kidney condition characterized by swelling in between the kidney tubules)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood glucose increased
Cholecystitis acute (rapid infection of gallbladder)

What are the existing conditions these people have? *

Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 7 people, 10.45%
Brain Neoplasm Malignant (brain cancer tumour): 7 people, 10.45%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 8.96%
Type 2 Diabetes: 5 people, 7.46%
Oligodendroglioma (a type of glioma that are believed to originate from the oligodendrocytes of the brain or from a glial precursor cell): 5 people, 7.46%
High Blood Pressure: 5 people, 7.46%
Sleep Disorder: 4 people, 5.97%
Nausea And Vomiting: 4 people, 5.97%
Nausea (feeling of having an urge to vomit): 4 people, 5.97%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 5.97%

* Approximation only. Some reports may have incomplete information.

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