Metformin and Wakix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin (metformin hydrochloride) and Wakix (pitolisant hydrochloride). Common drug interactions include back pain among females and cough among males.

The phase IV clinical study analyzes what interactions people have when they take Metformin and Wakix. It is created by eHealthMe based on reports of 79 people who take the same drugs from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

What is Wakix?

Wakix has active ingredients of pitolisant hydrochloride. eHealthMe is studying from 1,982 Wakix users. Check the latest studies of Wakix.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

79 people who take Metformin and Wakix together, and have interactions are studied.

What are the common drug interactions of Metformin and Wakix, by gender? *:

female:

Back pain
Blood potassium decreased
Concussion (short loss of normal brain function in response to a head injury)
Constipation
Cystitis interstitial (unknown cause characterized by bladder pain)
Delusion (a false belief or opinion)
Depression
Diarrhoea
Drug hypersensitivity
Dry eye (lack of adequate tears)

male:

Cough
Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight increased
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Disturbance in attention
Dyspnoea (difficult or laboured respiration)
Dysstasia (difficulty in standing)
Inflammation
Limb injury

What are the common drug interactions of Metformin and Wakix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Depression
Glycosylated haemoglobin increased
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight increased
Cough
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Oropharyngeal pain
Skin discolouration (change of skin colour)

20-29:

Drug ineffective
Hunger
Initial insomnia (feeling of inadequate or poor-quality sleep)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Poor quality sleep
Retching (strong involuntary effort to vomit)
Drug dependence
Hallucination (an experience involving the perception of something not present)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Impaired gastric emptying

30-39:

Ankylosing spondylitis (type of arthritis affecting the spine)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Blood cholesterol increased
Cerebral salt-wasting syndrome (low blood sodium concentration in brain)
Contusion (a type of hematoma of tissue in which capillaries)
Dyspnoea (difficult or laboured respiration)
Mania (a state of abnormally elevated or irritable mood)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Panic attack
Pruritus (severe itching of the skin)

40-49:

Anaemia (lack of blood)
Suicidal ideation
Bipolar disorder (mood disorder)
Blood pressure decreased
Headache (pain in head)
Self-injurious ideation
Therapeutic response unexpected
Blood pressure increased
Depression
Drug hypersensitivity

50-59:

Feeling hot
Hypnopompic hallucination
Skin infection
Nausea (feeling of having an urge to vomit)
Nightmare (unpleasant dream)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Malaise (a feeling of general discomfort or uneasiness)
Acute myocardial infarction (acute heart attack)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 72 people, 91.14%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 47 people, 59.49%
Drowsiness: 35 people, 44.30%

* Approximation only. Some reports may have incomplete information.

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