Methadone hydrochloride and Escitalopram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methadone hydrochloride (methadone hydrochloride) and Escitalopram (escitalopram oxalate). Common drug interactions include pneumonia among females and extrapyramidal disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Methadone hydrochloride and Escitalopram. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Methadone hydrochloride?

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 8,598 Methadone hydrochloride users. Check the latest studies of Methadone hydrochloride.

What is Escitalopram?

Escitalopram has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 78,082 Escitalopram users. Check the latest studies of Escitalopram.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 03, 2026

53 people who take Methadone hydrochloride and Escitalopram together, and have interactions are studied.

Methadone hydrochloride and Escitalopram drug interactions.

What are the common drug interactions of Methadone Hydrochloride and Escitalopram, by gender? *:

female:

Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Radiation pneumonitis (inflammation of lung due to radiation)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Arthralgia (joint pain)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Nausea (feeling of having an urge to vomit)
Agitation (state of anxiety or nervous excitement)
Blood cholesterol increased

male:

Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Fatigue (feeling of tiredness)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Anaemia (lack of blood)
Asthenia (weakness)
Coma (state of unconsciousness lasting more than six hours)
Cytolytic hepatitis (dissolution or destruction of a liver cell)
Death
Diarrhoea neonatal (diarrhoea in babies)
Drug toxicity

What are the common drug interactions of Methadone Hydrochloride and Escitalopram, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthralgia (joint pain)
Osteonecrosis (death of bone)

20-29:

Death

30-39:

Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Diarrhoea
Agitation (state of anxiety or nervous excitement)
Blood cholesterol increased
Blood thyroid stimulating hormone increased
High density lipoprotein increased
Nausea (feeling of having an urge to vomit)
Overdose
Total cholesterol/hdl ratio decreased

40-49:

Blood urine present
Decreased appetite
Fatigue (feeling of tiredness)
Coma (state of unconsciousness lasting more than six hours)
Logorrhoea (excessive, uncontrollable, or incoherent talkativeness)
Methaemoglobinaemia (a disorder characterized by the presence of a higher than normal level of methemoglobin in blood)
Mood swings (an extreme or rapid change in mood)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Restlessness (not able to rest)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

50-59:

Anaemia (lack of blood)
Asthenia (weakness)
Oesophagitis (inflammation of oesophagus)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Somnolence (a state of near-sleep, a strong desire for sleep)

60+:

Pulmonary embolism (blockage of the main artery of the lung)
Pneumonia
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Overdose
Thrombosis (formation of a blood clot inside a blood vessel)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Radiation pneumonitis (inflammation of lung due to radiation)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Rash erythematous (redness of the skin)

What are the existing conditions these people have? *

Pneumonia: 13 people, 24.53%
Non-Small Cell Lung Cancer Stage 0: 12 people, 22.64%
Lung Cancer - Non-Small Cell (lung cancer): 5 people, 9.43%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 7.55%
Stress And Anxiety: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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