Methadose and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methadose (methadone hydrochloride) and Zoloft (sertraline hydrochloride). Common drug interactions include premature delivery among females and overdose among males.

The phase IV clinical study analyzes what interactions people have when they take Methadose and Zoloft. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Methadose?

Methadose has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 5,101 Methadose users. Check the latest studies of Methadose.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

On Jul, 12, 2026

24 people who take Methadose and Zoloft together, and have interactions are studied.

What are the common drug interactions of Methadose and Zoloft, by gender? *:

female:

Premature delivery
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Nausea (feeling of having an urge to vomit)
Dizziness
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Muscle cramp (painful sensation caused by muscle contraction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Thrombosis (formation of a blood clot inside a blood vessel)

male:

Overdose
Death
Coronary artery atherosclerosis (life-threatening blockages in the arteries of your heart)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic coma
Diabetic hyperosmolar coma (diabetes coma due to extremely high blood sugar (glucose) levels; extreme lack of water (dehydration))
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic ulcer
Drug ineffective

What are the common drug interactions of Methadose and Zoloft, by age (0-1 to 60+)? *:

0-1:

Electrocardiogram qt prolonged
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)

2-9:

n/a

10-19:

n/a

20-29:

Death
Blood pressure increased
Diarrhoea
Drug toxicity
Maternal exposure during pregnancy (use of substance during pregnancy)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Premature delivery

30-39:

Dizziness
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Multiple drug overdose accidental
Muscle cramp (painful sensation caused by muscle contraction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Overdose
Thrombosis (formation of a blood clot inside a blood vessel)
Vomiting

40-49:

Cardiomegaly (increased size of heart than normal)
Chronic kidney disease
Coronary artery atherosclerosis (life-threatening blockages in the arteries of your heart)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Diabetic coma
Diabetic hyperosmolar coma (diabetes coma due to extremely high blood sugar (glucose) levels; extreme lack of water (dehydration))
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic ulcer
Dyspnoea (difficult or laboured respiration)
Hypertension (high blood pressure)

50-59:

Ammonia increased
Asthenia (weakness)
Cardiac disorder
Confusional state
Constipation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fatigue (feeling of tiredness)
Hypersomnia (excessive daytime sleepiness (eds))
Spinal cord injury
White blood cell disorder

60+:

Asthenia (weakness)
Blood pressure increased
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Visual impairment
C-reactive protein increased
Drug ineffective
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Influenza like illness

What are the existing conditions these people have? *

Back Pain: 7 people, 29.17%
Stress And Anxiety: 6 people, 25.00%
Headache (pain in head): 5 people, 20.83%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 20.83%
High Blood Cholesterol: 5 people, 20.83%
Hypersensitivity: 4 people, 16.67%
High Blood Pressure: 4 people, 16.67%
Sleep Disorder: 4 people, 16.67%
Neuralgia (pain in one or more nerves): 4 people, 16.67%
Quit Smoking: 4 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Methadose and Zoloft?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously