Methimazole and Ambien drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methimazole (methimazole) and Ambien (zolpidem tartrate). Common drug interactions include neuropathy peripheral among females and asthma among males.

The phase IV clinical study analyzes what interactions people have when they take Methimazole and Ambien. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Methimazole?

Methimazole has active ingredients of methimazole. It is often used in hyperthyroidism. eHealthMe is studying from 8,016 Methimazole users. Check the latest studies of Methimazole.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,519 Ambien users. Check the latest studies of Ambien.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

77 people who take Methimazole and Ambien together, and have interactions are studied.

Methimazole and Ambien drug interactions.

What are the common drug interactions of Methimazole and Ambien, by gender? *:

female:

Neuropathy peripheral (surface nerve damage)
Oesophagitis (inflammation of oesophagus)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Irritable bowel syndrome
Abdominal pain
Arthralgia (joint pain)
Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dyspnoea (difficult or laboured respiration)
Emotional distress

male:

Asthma
Diarrhoea
Anaemia (lack of blood)
Anxiety
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrioventricular block first degree (heart block first degree)
Back pain
Blood creatinine increased

What are the common drug interactions of Methimazole and Ambien, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hypersensitivity
Poor venous access
Colitis (inflammation of colon)
Impaired gastric emptying
Oesophagitis (inflammation of oesophagus)
Contusion (a type of hematoma of tissue in which capillaries)
Irritable bowel syndrome
Abdominal distension
Diarrhoea
Drug ineffective

30-39:

Blood pressure increased
Confusional state
Crying
Drug ineffective
Fatigue (feeling of tiredness)
Feeling drunk
Heart rate increased
Limb injury
Localised infection (infection at the single location)
Muscle spasms (muscle contraction)

40-49:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Asthenia (weakness)
Depression
Dizziness
Abdominal pain
Anxiety
Back pain
Blood thyroid stimulating hormone decreased
Dyspnoea (difficult or laboured respiration)

50-59:

Arthralgia (joint pain)
Cardiomyopathy (weakening of the heart muscle)
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Heart injury
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic failure (liver failure)
Hepatitis (inflammation of the liver)

60+:

Fall
Neuropathy peripheral (surface nerve damage)
Anaemia (lack of blood)
Angioedema (rapid swelling of the dermis)
Back pain
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blood cholesterol increased
Blood creatinine increased
Blood pressure increased
Blood urea increased

What are the existing conditions these people have? *

Stress And Anxiety: 12 people, 15.58%
Pain: 11 people, 14.29%
Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 10 people, 12.99%
Birth Control: 8 people, 10.39%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 9.09%
Multiple Myeloma (cancer of the plasma cells): 7 people, 9.09%
Basedow's Disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones): 7 people, 9.09%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 7.79%
Depression: 6 people, 7.79%
High Blood Pressure: 5 people, 6.49%

* Approximation only. Some reports may have incomplete information.

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