Methimazole and Uptravi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methimazole (methimazole) and Uptravi (selexipag). Common drug interactions include cough among females and pulmonary arterial hypertension among males.

The phase IV clinical study analyzes what interactions people have when they take Methimazole and Uptravi. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Methimazole?

Methimazole has active ingredients of methimazole. It is often used in hyperthyroidism. eHealthMe is studying from 8,016 Methimazole users. Check the latest studies of Methimazole.

What is Uptravi?

Uptravi has active ingredients of selexipag. eHealthMe is studying from 26,576 Uptravi users. Check the latest studies of Uptravi.

On Jul, 30, 2026

18 people who take Methimazole and Uptravi together, and have interactions are studied.

Methimazole and Uptravi drug interactions.

What are the common drug interactions of Methimazole and Uptravi, by gender? *:

female:

Cough
Catheter site infection (infection at the site of insertion)
Flushing (the warm, red condition of human skin)
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Abdominal distension
Anxiety
Asthenia (weakness)
Chest pain
Depressed mood

male:

Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
N-terminal prohormone brain natriuretic peptide increased
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Oxygen saturation decreased

What are the common drug interactions of Methimazole and Uptravi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cough
Diarrhoea
Epistaxis (bleed from the nose)
Flushing (the warm, red condition of human skin)
Headache (pain in head)

30-39:

Catheter site infection (infection at the site of insertion)
Haemodynamic instability (disturbances in the blood movement in our body)

40-49:

Abdominal distension
Anxiety
Chest pain
Depressed mood
Diarrhoea
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Infusion site bruising
Infusion site exfoliation (removal of the oldest dead skin from infusion site)

50-59:

Device related infection
Diarrhoea
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Headache (pain in head)
Pruritus (severe itching of the skin)
Renal impairment (severely reduced kidney function)
Hypotension (abnormally low blood pressure)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)

60+:

N-terminal prohormone brain natriuretic peptide increased
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Blood urea increased
Cardiac failure
Cardiac failure congestive
Cough
Drug hypersensitivity
Fatigue (feeling of tiredness)
Fluid overload (too much fluid in the blood)
Gait disturbance

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 17 people, 94.44%
Infusion Site Pain: 5 people, 27.78%
Basedow's Disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones): 5 people, 27.78%
Urination - Excessive Volume: 3 people, 16.67%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 3 people, 16.67%
Cardiac Failure: 3 people, 16.67%
Hiv Infection: 2 people, 11.11%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 5.56%
Neuropathy Peripheral (surface nerve damage): 1 person, 5.56%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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