Methotrexate and Carbidopa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Carbidopa (carbidopa). Common drug interactions include haemoglobin decreased among females and arterial occlusive disease among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Carbidopa. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,314 Methotrexate users. Check the latest studies of Methotrexate.

What is Carbidopa?

Carbidopa has active ingredients of carbidopa. It is often used in parkinson's disease. eHealthMe is studying from 3,061 Carbidopa users. Check the latest studies of Carbidopa.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

43 people who take Methotrexate and Carbidopa together, and have interactions are studied.

Methotrexate and Carbidopa drug interactions.

What are the common drug interactions of Methotrexate and Carbidopa, by gender? *:

female:

Haemoglobin decreased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Pneumonia
Drug hypersensitivity
Large intestinal ulcer
Acute respiratory failure
Anaemia (lack of blood)
Death
Dizziness
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)

male:

Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arthralgia (joint pain)
Hallucination (an experience involving the perception of something not present)
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Joint swelling
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pneumonia
Pyrexia (fever)

What are the common drug interactions of Methotrexate and Carbidopa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arthralgia (joint pain)
Blood cholesterol increased
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Joint swelling
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

60+:

Haemoglobin decreased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Vomiting
Anxiety
Arthralgia (joint pain)
Blood magnesium decreased
Blood potassium decreased
Chills (felling of cold)
Cholecystitis (infection of gallbladder)
Cholecystitis infective (infection of gallbladder capable to infect other organs)

What are the existing conditions these people have? *

Pain: 8 people, 18.60%
Irritable Bowel Syndrome: 5 people, 11.63%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 11.63%
Gout (uric acid crystals building up in the body): 5 people, 11.63%
Constipation: 5 people, 11.63%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 11.63%
Swelling: 4 people, 9.30%
Sleep Disorder: 4 people, 9.30%
Retinal Vessel Occlusion (a blockage in one of the small arteries): 4 people, 9.30%
Osteoporosis (bones weak and more likely to break): 4 people, 9.30%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and Carbidopa?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously