Methotrexate and Cider vinegar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Cider vinegar (apple cider vinegar). Common drug interactions include bronchitis among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Cider vinegar. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

What is Cider vinegar?

Cider vinegar has active ingredients of apple cider vinegar. It is often used in weight loss. eHealthMe is studying from 1,517 Cider vinegar users. Check the latest studies of Cider vinegar.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

70 people who take Methotrexate and Cider vinegar together, and have interactions are studied.

Methotrexate and Cider vinegar drug interactions.

What are the common drug interactions of Methotrexate and Cider Vinegar, by gender? *:

female:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Arthropathy
Nausea (feeling of having an urge to vomit)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Urinary tract infection
Weight decreased
White blood cell count decreased
Headache (pain in head)
Infection

male:

Drug ineffective
Headache (pain in head)
Muscular weakness (muscle weakness)
Pain in extremity
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Haemoglobin decreased
Infection

What are the common drug interactions of Methotrexate and Cider Vinegar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Laryngitis (inflammation of the larynx)
Upper respiratory tract infection
Infusion site extravasation (flow of (blood or lymph) from infusion site)

30-39:

Anaemia (lack of blood)
Vitamin d deficiency

40-49:

Sinusitis (inflammation of sinus)
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Abdominal pain upper
Adverse event
Alopecia (absence of hair from areas of the body)
Blood cholesterol increased
Constipation
Diabetic foot
Drug ineffective
Dyspepsia (indigestion)

50-59:

Headache (pain in head)
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Drug ineffective
Fatigue (feeling of tiredness)
Pain in extremity
Ankle fracture
Arthralgia (joint pain)
Atrioventricular block (heart block)
Atrophy (wasting away of a part of the body)

60+:

Drug ineffective
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Device related infection
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Abdominal pain lower
Blood cholesterol increased
Crying
Dehydration (dryness resulting from the removal of water)
Depression
Diarrhoea

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 13 people, 18.57%
Psoriasis (immune-mediated disease that affects the skin): 7 people, 10.00%
Pain: 4 people, 5.71%
Cardiac Disorder: 4 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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