Methotrexate and Fentanyl transdermal system drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Fentanyl transdermal system (fentanyl). Common drug interactions include breast disorder among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Fentanyl transdermal system. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,314 Methotrexate users. Check the latest studies of Methotrexate.

What is Fentanyl transdermal system?

Fentanyl transdermal system has active ingredients of fentanyl. It is often used in pain. eHealthMe is studying from 5,728 Fentanyl transdermal system users. Check the latest studies of Fentanyl transdermal system.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

49 people who take Methotrexate and Fentanyl transdermal system together, and have interactions are studied.

Methotrexate and Fentanyl transdermal system drug interactions.

What are the common drug interactions of Methotrexate and Fentanyl Transdermal System, by gender? *:

female:

Breast disorder
Contusion (a type of hematoma of tissue in which capillaries)
Eye swelling
Fungal infection
Nail discolouration (change in nail colour)
Neuralgia (pain in one or more nerves)
Oedema peripheral (superficial swelling)
Rash
Secretion discharge
Soft tissue injury

male:

Drug ineffective
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Clostridial infection (infectious conditions by clostridium bacteria)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Depression
Disease progression
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)
Immune system disorder

What are the common drug interactions of Methotrexate and Fentanyl Transdermal System, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cardiac failure
Depressed level of consciousness
Electrocardiogram st-t change
Face oedema (swelling of face)
Febrile neutropenia (fever with reduced white blood cells)
Fluid overload (too much fluid in the blood)
General physical health deterioration (weak health status)
Haematemesis (vomiting of blood)
Hepatitis (inflammation of the liver)
Hypertension (high blood pressure)

20-29:

Drug ineffective

30-39:

Drug ineffective
Hot flush (sudden feelings of heat)
Muscle twitching
Nasopharyngitis (inflammation of the nasopharynx)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Candida sepsis (candida in blood stream)
Cardiac failure congestive
Engraft failure
Renal disorder (kidney disease)

40-49:

Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Tobacco user
Drug ineffective
Fatigue (feeling of tiredness)
Headache (pain in head)
Acute hepatic failure
Anxiety
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Depression
Dizziness

50-59:

Abasia (inability to walk)
Alopecia (absence of hair from areas of the body)
Application site erythema (redness of the skin at application site)
Application site pruritus (application site severe itching of the skin)
Asthenia (weakness)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dyspnoea (difficult or laboured respiration)
Eyelid ptosis (falling of the upper or lower eyelid)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

60+:

Drug ineffective
Blood creatinine increased
Epigastric discomfort
Fatigue (feeling of tiredness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Infection
Nausea (feeling of having an urge to vomit)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteopenia (a condition where bone mineral density is lower than normal)
Pleural fibrosis (formation of fibrous tissue in lung)

What are the existing conditions these people have? *

Arthritis (form of joint disorder that involves inflammation of one or more joints): 9 people, 18.37%
High Blood Pressure: 7 people, 14.29%
Sleep Disorder: 7 people, 14.29%
Back Pain: 6 people, 12.24%
Depression: 5 people, 10.20%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 10.20%
High Blood Cholesterol: 4 people, 8.16%
Urine Abnormality: 4 people, 8.16%
Migraine (headache): 4 people, 8.16%
Thyroid Diseases: 4 people, 8.16%

* Approximation only. Some reports may have incomplete information.

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