Methotrexate and Hexadrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Hexadrol (dexamethasone). Common drug interactions include general physical health deterioration among females and weight decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Hexadrol. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Hexadrol?

Hexadrol has active ingredients of dexamethasone. eHealthMe is studying from 434 Hexadrol users. Check the latest studies of Hexadrol.

On Jul, 29, 2026

41 people who take Methotrexate and Hexadrol together, and have interactions are studied.

Methotrexate and Hexadrol drug interactions.

What are the common drug interactions of Methotrexate and Hexadrol, by gender? *:

female:

General physical health deterioration (weak health status)
Gingival bleeding (bleeding gums)
Left ventricular dysfunction
Ligament injury
Lymphadenopathy (disease or enlargement of lymph nodes)
Lymphatic system neoplasm (tumour of lymphatic system)
Lymphoedema (localized fluid retention and tissue swelling)
Metastases to lung (cancer spreads to lung)
Mitral valve incompetence (inefficient heart valve)
Mouth haemorrhage (bleeding from mouth)

male:

Weight decreased
Hepatobiliary disease (diseases affect the liver and/or biliary tract)
Stomatitis (inflammation of mucous membrane of mouth)
White blood cell count decreased
Pyrexia (fever)
Thrombocytopenia (decrease of platelets in blood)
Anaemia (lack of blood)
Acute lymphocytic leukaemia (cancer of the white blood cells)
Back pain
Infection

What are the common drug interactions of Methotrexate and Hexadrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Leukopenia (less number of white blood cells in blood)
Respiratory distress (difficulty in breathing)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Thrombocytopenia (decrease of platelets in blood)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Disseminated cryptococcosis (one of the acquired immune deficiency syndrome defining criteria and the most common cause of life threatening meningitis)
Drug ineffective
Hepatomegaly (abnormal enlargement of the liver)
Increased appetite
Liver fatty (fat deposition of liver)

10-19:

Hepatobiliary disease (diseases affect the liver and/or biliary tract)
Weight decreased
White blood cell count decreased
Hypokalaemia (low potassium)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Febrile neutropenia (fever with reduced white blood cells)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Lung infection

20-29:

n/a

30-39:

Acute lymphocytic leukaemia (cancer of the white blood cells)
Anaemia (lack of blood)
Back pain
Neck pain
Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Thrombocytopenia (decrease of platelets in blood)

40-49:

Pulmonary hypertension (increase in blood pressure in the lung artery)
Rectal cancer (cancer of rectum)
Seasonal allergy (allergic condition due to certain season)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tobacco abuse
Tricuspid valve incompetence (inefficient heart valve)
Weight increased
Gallbladder disorder
Hepatic steatosis (fatty liver disease)

50-59:

Cardiovascular disorder (heart diseases)
Chest pain
Dyspnoea (difficult or laboured respiration)
Syncope (loss of consciousness with an inability to maintain postural tone)
Anaemia (lack of blood)
Asthenia (weakness)
Blood bilirubin increased
Carcinoembryonic antigen increased
Cerebral toxoplasmosis (parasitic disease of brain caused by the protozoan toxoplasma gondii)
Conjunctival pallor (a pale colour of conjunctiva)

60+:

Infection
Anaemia (lack of blood)
Fracture
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Impaired healing
Lymphadenopathy (disease or enlargement of lymph nodes)
Lymphoma (cancer that begins in immune system cells)
Malignant neoplasm progression (cancer tumour came back)
Mastication disorder (disease of chewing food)
Oral soft tissue disorder (oral soft tissue disease)

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 8 people, 19.51%
Anaplastic Large Cell Lymphoma T- And Null-Cell Types (t-cell or null-cell cancer, a type of blood cancer): 4 people, 9.76%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and Hexadrol?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously