Methotrexate and Msm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Msm (methylsulfonylmethane). Common drug interactions include malaise among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Msm. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Msm?

Msm has active ingredients of methylsulfonylmethane. It is often used in joint pain. eHealthMe is studying from 1,210 Msm users. Check the latest studies of Msm.

On Jul, 19, 2026

50 people who take Methotrexate and Msm together, and have interactions are studied.

What are the common drug interactions of Methotrexate and Msm, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Joint swelling
Nausea (feeling of having an urge to vomit)
Mobility decreased (ability to move is reduced)
Urinary tract infection
Headache (pain in head)
Anaemia (lack of blood)
Eye irritation
Eye pain
Infection

male:

Pain
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Cataract (clouding of the lens inside the eye)
Cataract operation complication
Hip fracture
Surgical failure
Visual impairment

What are the common drug interactions of Methotrexate and Msm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abortion spontaneous (naturally occurring miscarriage)
Anti-cyclic citrullinated peptide antibody positive
Back pain
Decreased appetite
Headache (pain in head)
Inflammatory marker increased
Joint effusion (presence of extra fluid in joint covering)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Joint swelling

30-39:

n/a

40-49:

Eye pain
Infection
Kidney infection
Pain
Peripheral swelling
Pulmonary embolism (blockage of the main artery of the lung)
Thrombosis (formation of a blood clot inside a blood vessel)
Urinary tract infection
Mobility decreased (ability to move is reduced)
Injection site erythema (redness at injection site)

50-59:

Drug ineffective
Oropharyngeal pain
Acne (skin problems that cause pimples)
Anal haemorrhage
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Diarrhoea haemorrhagic (bloody diarrhoea)
Drug hypersensitivity
Dysphonia (speech disorder attributable to a disorder of phonation)
Eyelid exfoliation
Pain

60+:

Pain
Blood cholesterol increased
Chills (felling of cold)
Cough
Drug ineffective
Eye disorder
Feeling cold
Infusion related reaction
Nerve compression
Osteoporosis (bones weak and more likely to break)

What are the existing conditions these people have? *

Pain: 10 people, 20.00%
Bone Disorder: 5 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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