Methotrexate and Papain drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Papain (papain). Common drug interactions include abdominal discomfort among females.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Papain. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

What is Papain?

Papain has active ingredients of papain. eHealthMe is studying from 127 Papain users. Check the latest studies of Papain.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

24 people who take Methotrexate and Papain together, and have interactions are studied.

Methotrexate and Papain drug interactions.

What are the common drug interactions of Methotrexate and Papain, by gender? *:

female:

Abdominal discomfort
Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach)
Alopecia (absence of hair from areas of the body)
Arthropathy
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Drug ineffective
Drug intolerance (drug sensitivity)
Dyspnoea (difficult or laboured respiration)
Folliculitis (infection of hair root)
Gastrointestinal disorder (functional problems of gastrointestinal tract)

male:

n/a

What are the common drug interactions of Methotrexate and Papain, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Fatigue (feeling of tiredness)
Folliculitis (infection of hair root)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Glossodynia (a burning or painful sensation in the tongue)
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Hepatic enzyme increased
Hypersensitivity
Impaired healing
Infection
Infusion related reaction

50-59:

n/a

60+:

Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Dizziness
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Erythema (redness of the skin)
Fall
Head injury
Headache (pain in head)
Hypertension (high blood pressure)
Hypoxia (low oxygen in tissues)

What are the existing conditions these people have? *

Osteoarthritis (a joint disease caused by cartilage loss in a joint): 7 people, 29.17%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 25.00%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 5 people, 20.83%
Joint Pain: 5 people, 20.83%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 16.67%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 12.50%
Inflammation: 2 people, 8.33%
Indigestion: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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