Methotrexate and Phytonadione drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Phytonadione (phytonadione). Common drug interactions include blister among females and hypoxia among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Phytonadione. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Phytonadione?

Phytonadione has active ingredients of phytonadione. It is often used in hemorrhagic stroke. eHealthMe is studying from 2,870 Phytonadione users. Check the latest studies of Phytonadione.

On Jul, 26, 2026

97 people who take Methotrexate and Phytonadione together, and have interactions are studied.

Methotrexate and Phytonadione drug interactions.

What are the common drug interactions of Methotrexate and Phytonadione, by gender? *:

female:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blister infected (infection of small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Foot fracture
Ingrowing nail
Skin exfoliation (removal of the oldest dead skin cells)
Tooth disorder (tooth disease)
Hypotension (abnormally low blood pressure)
Sepsis (a severe blood infection that can lead to organ failure and death)
Respiratory failure (inadequate gas exchange by the respiratory system)
Diarrhoea

male:

Hypoxia (low oxygen in tissues)
Neuropathy peripheral (surface nerve damage)
Acute lymphocytic leukaemia (cancer of the white blood cells)
Agitation (state of anxiety or nervous excitement)
Ammonia increased
Apnoea (suspension of external breathing)
Chest discomfort
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
Coagulopathy (blood's ability to clot is impaired)
Confusional state

What are the common drug interactions of Methotrexate and Phytonadione, by age (0-1 to 60+)? *:

0-1:

Abdominal compartment syndrome (increased pressure in abdomen)
Ascites (accumulation of fluid in the abdominal cavity)
Blood lactic acid increased
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coagulopathy (blood's ability to clot is impaired)
Duodenal perforation (complication of duodenal ulcer)
Enterococcal infection
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

2-9:

Pulmonary hypertension (increase in blood pressure in the lung artery)
Restrictive cardiomyopathy (a condition in which the walls of the lower chambers of the heart (the ventricles) are abnormally rigid and lack the flexibility)
Heart transplant
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Delirium (wild excitement)
Depressed level of consciousness
Hypernatraemia (an abnormally high plasma concentration of sodium ions)

10-19:

Coagulopathy (blood's ability to clot is impaired)
Neuropathy peripheral (surface nerve damage)
Pericardial effusion (fluid around the heart)
Respiratory disorder (respiratory disease)
Atelectasis (partial or complete collapse of the lung)
Cough
Hypoxia (low oxygen in tissues)
Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Acute lymphocytic leukaemia (cancer of the white blood cells)

20-29:

Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Acute respiratory failure
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Herpes zoster ophthalmic (eye infection caused by varicella-zoster virus (vzv))
Pneumonia
Pneumonia fungal
Pneumonia viral
Pulmonary haemorrhage (acute bleeding from the lung)
Pulmonary oedema (fluid accumulation in the lungs)

30-39:

Pneumonia
Pruritus (severe itching of the skin)
Septic shock (shock due to blood infection)

40-49:

Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Hypersensitivity
Acute lymphocytic leukaemia (cancer of the white blood cells)
Multi-organ failure (multisystem organ failure)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

50-59:

Cellulitis (infection under the skin)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blister infected (infection of small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Foot fracture
Ingrowing nail
Skin exfoliation (removal of the oldest dead skin cells)
Tooth disorder (tooth disease)
Pustular psoriasis (raised bumps on the skin that are filled with pus)
Acute hepatic failure
Drug ineffective

60+:

Hypotension (abnormally low blood pressure)
Sepsis (a severe blood infection that can lead to organ failure and death)
Anaemia (lack of blood)
Cerebrovascular disorder (disease of brain)
General physical health deterioration (weak health status)
Haemorrhage intracranial (bleeding within the skull)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Small intestinal obstruction (blockage in small intestine)
Bacterial toxaemia (blood contains bacterial toxins)
Cardiac failure congestive

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 15 people, 15.46%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 13 people, 13.40%
Nausea And Vomiting: 8 people, 8.25%
Nausea (feeling of having an urge to vomit): 8 people, 8.25%
High Blood Pressure: 8 people, 8.25%
Pain: 7 people, 7.22%
Septic Shock (shock due to blood infection): 6 people, 6.19%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 6.19%
Diarrhea: 6 people, 6.19%
Shock Haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding): 5 people, 5.15%

* Approximation only. Some reports may have incomplete information.

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