Methotrexate and Zyban drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Zyban (bupropion hydrochloride). Common drug interactions include acute myeloid leukaemia among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Zyban. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Zyban?

Zyban has active ingredients of bupropion hydrochloride. It is often used in quit smoking. eHealthMe is studying from 8,029 Zyban users. Check the latest studies of Zyban.

On Jul, 26, 2026

26 people who take Methotrexate and Zyban together, and have interactions are studied.

Methotrexate and Zyban drug interactions.

What are the common drug interactions of Methotrexate and Zyban, by gender? *:

female:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Anger
Anxiety disorder
Appendicitis (inflammation of the appendix)
Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood alkaline phosphatase increased
Blood chloride decreased
Blood glucose increased

male:

Abdominal pain
Aspartate aminotransferase increased
Nephrolithiasis (calculi in the kidneys)
Prostate cancer
Small intestinal obstruction (blockage in small intestine)
Surgery
Urinary retention (the inability to completely or partially empty the bladder)
Weight increased
Benign prostatic hyperplasia (benign enlargement of the prostate)
Blood pressure increased

What are the common drug interactions of Methotrexate and Zyban, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anaemia (lack of blood)
Arthralgia (joint pain)
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)
Optic nerve disorder (disease of optic nerve)
Pericardial effusion (fluid around the heart)
Photophobia (extreme sensitivity to light)
Pleural effusion (water on the lungs)
Pyrexia (fever)

10-19:

n/a

20-29:

n/a

30-39:

Acute respiratory distress syndrome
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer)
Periodontal disease (disease that attacks the gum and bone and around the teeth)
Anosmia (partial or complete loss of the sense of smell)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Renal failure (kidney dysfunction)
Renal insufficiency (insufficient excretion of wastes by the kidneys)

40-49:

Cellulitis (infection under the skin)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Contusion (a type of hematoma of tissue in which capillaries)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cyst (a closed sac)
Diarrhoea
Dyspnoea exertional (breathlessness or shortness of breath)
Dysuria (painful or difficult urination)
Epicondylitis (tennis elbow)
Fatigue (feeling of tiredness)

50-59:

Abdominal pain
Blood pressure increased
Drug ineffective
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Rhinorrhoea (watery mucus discharge from the nose)
Vomiting
Abdominal discomfort
Abdominal distension
Abdominal pain lower

60+:

Abdominal discomfort
Anaemia (lack of blood)
Gastrointestinal pain
Haematocrit decreased
Haemoglobin decreased
Hip fracture
Hypoaesthesia (reduced sense of touch or sensation)
Incisional hernia (hernia caused by an incompletely-healed surgical wound)
Livedo reticularis (a lace-like purplish discoloration of the skin)
Lupus-like syndrome (a disease symptom matches with lupus an immune disease)

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 11.54%
Seasonal Allergy (allergic condition due to certain season): 2 people, 7.69%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 7.69%
Migraine (headache): 2 people, 7.69%
Joint Pain: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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