Methoxsalen and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methoxsalen (methoxsalen) and Diphen (diphenhydramine hydrochloride). Common drug interactions include weight increased among females and eosinophil count increased among males.

The phase IV clinical study analyzes what interactions people have when they take Methoxsalen and Diphen. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Methoxsalen?

Methoxsalen has active ingredients of methoxsalen. eHealthMe is studying from 153 Methoxsalen users. Check the latest studies of Methoxsalen.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

On Jul, 11, 2026

13 people who take Methoxsalen and Diphen together, and have interactions are studied.

Methoxsalen and Diphen drug interactions.

What are the common drug interactions of Methoxsalen and Diphen, by gender? *:

female:

Weight increased
Wound
Abdominal distension
Anaemia of chronic disease
Arthralgia (joint pain)
Cataract (clouding of the lens inside the eye)
Depressed mood
Febrile neutropenia (fever with reduced white blood cells)
Flat affect (absence of emotional response to a situation)
Iron deficiency anaemia

male:

Eosinophil count increased
Hypersensitivity

What are the common drug interactions of Methoxsalen and Diphen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac failure
Drug intolerance (drug sensitivity)
Dysphagia (a condition in which swallowing is difficult or painful)
Vomiting

30-39:

Depressed mood
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)
Flat affect (absence of emotional response to a situation)
Iron deficiency anaemia
Leukocytosis (increased white blood cells)
Neuropathy peripheral (surface nerve damage)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)

40-49:

Abdominal discomfort
Abdominal pain upper
Asthenia (weakness)
Asthma
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood cholesterol increased
Bone erosion
Breast cancer stage iii
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 6 people, 46.15%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 6 people, 46.15%
Chronic Graft Versus Host Disease (immune cells attack the host's body cells after transplant): 4 people, 30.77%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 7.69%
Sleep Disorder: 1 person, 7.69%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 7.69%
Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 7.69%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 7.69%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 7.69%
Oedema (fluid collection in tissue): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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