Methyldopa and Bactrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methyldopa (methyldopa) and Bactrim (sulfamethoxazole; trimethoprim). Common drug interactions include drug screen positive among females and hypercalcaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Methyldopa and Bactrim. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Methyldopa?

Methyldopa has active ingredients of methyldopa. It is often used in high blood pressure. eHealthMe is studying from 6,475 Methyldopa users. Check the latest studies of Methyldopa.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

On Jul, 18, 2026

26 people who take Methyldopa and Bactrim together, and have interactions are studied.

Methyldopa and Bactrim drug interactions.

What are the common drug interactions of Methyldopa and Bactrim, by gender? *:

female:

Drug screen positive
Dyspnoea (difficult or laboured respiration)
Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gait disturbance
Glycosylated haemoglobin increased
Heart rate increased
Hepatic enzyme increased
Hyperkalaemia (damage to or disease of the kidney)

male:

Hypercalcaemia (elevated calcium (ca+) level in the blood)
Keratitis fungal (inflammation of the cornea due to fungal organism)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Amniotic fluid volume decreased
Anaemia (lack of blood)
Asthenia (weakness)
Blood parathyroid hormone decreased
Body temperature increased
Chills (felling of cold)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)

What are the common drug interactions of Methyldopa and Bactrim, by age (0-1 to 60+)? *:

0-1:

Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Low birth weight baby
Oligohydramnios (a condition in pregnancy characterized by a deficiency of amniotic fluid)
Temperature regulation disorder (body is unable to maintain temperature)

2-9:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Pancreatitis (inflammation of pancreas)

10-19:

Body temperature increased
Haematocrit decreased
Haemoglobin decreased
Heart rate increased
Platelet count increased
Reticulocyte count decreased
Reticulocyte count increased

20-29:

Renal tubular necrosis (death of kidney tubules)
Sinusitis (inflammation of sinus)
Urinary fistula
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Lower respiratory tract infection
Renal impairment (severely reduced kidney function)

30-39:

Renal failure (kidney dysfunction)
Renal mass (mass in kidney)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Drug exposure during pregnancy
Amniotic fluid volume decreased
Placental disorder
Pregnancy
Premature baby
Proteinuria (presence of protein in the urine)
Abortion spontaneous (naturally occurring miscarriage)

40-49:

n/a

50-59:

Abdominal tenderness
Anaemia (lack of blood)
Anaemia macrocytic (a macrocytic class of anaemia)
Anal sphincter atony (anal muscles are weak and cannot ensure an efficient sealing, this is called a sphincter atony)
Antinuclear antibody positive
Anxiety
Arthralgia (joint pain)
Asthma
Back pain
Bile duct stone

60+:

Glomerulosclerosis (a hardening of the glomerulus in the kidney)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Oliguria (not enough urine)
Renal atrophy (wasting of kidney)
Urine abnormality
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Keratitis fungal (inflammation of the cornea due to fungal organism)

What are the existing conditions these people have? *

Diabetes: 6 people, 23.08%
Muscle Aches (muscle pain): 5 people, 19.23%
Pain: 4 people, 15.38%
High Blood Cholesterol: 4 people, 15.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 15.38%
Pre-Eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman): 2 people, 7.69%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 7.69%
Microsporidia Infection (infection with microsporidia): 2 people, 7.69%
Menopausal Symptoms: 2 people, 7.69%
Infection: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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