Methyldopa and Clopidogrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methyldopa (methyldopa) and Clopidogrel (clopidogrel). Common drug interactions include alopecia among females and premature baby among males.

The phase IV clinical study analyzes what interactions people have when they take Methyldopa and Clopidogrel. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Methyldopa?

Methyldopa has active ingredients of methyldopa. It is often used in high blood pressure. eHealthMe is studying from 6,475 Methyldopa users. Check the latest studies of Methyldopa.

What is Clopidogrel?

Clopidogrel has active ingredients of clopidogrel. It is often used in blood clots. eHealthMe is studying from 92,160 Clopidogrel users. Check the latest studies of Clopidogrel.



On Jul, 13, 2026

45 people who take Methyldopa and Clopidogrel together, and have interactions are studied.

Methyldopa and Clopidogrel drug interactions.

What are the common drug interactions of Methyldopa and Clopidogrel, by gender? *:

female:

  1. Alopecia (absence of hair from areas of the body)
  2. Angina pectoris (chest pain due to ischemia of the heart muscle)
  3. Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
  4. Anxiety
  5. Aortic valve incompetence
  6. Arthralgia (joint pain)
  7. Asthenia (weakness)
  8. Blood glucose decreased
  9. Blood glucose increased
  10. Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)

male:

  1. Premature baby
  2. Diarrhoea
  3. Dyspnoea (difficult or laboured respiration)
  4. Electrocardiogram st segment depression
  5. Gout (uric acid crystals building up in the body)
  6. Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
  7. Hypocalcaemia (levels of calcium in blood serum are abnormally low)
  8. Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
  9. Myalgia (muscle pain)
  10. Oxygen saturation decreased

What are the common drug interactions of Methyldopa and Clopidogrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Hyperhidrosis (abnormally increased sweating)
  2. Hypoxia (low oxygen in tissues)
  3. Peripartum cardiomyopathy (deterioration in cardiac function presenting typically between the last month of pregnancy and up to five months postpartum)
  4. Pulmonary hypertension (increase in blood pressure in the lung artery)
  5. Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
  6. Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
  7. Cardiac death
  8. Cardiac murmur (an heart sound in valve abnormality)
  9. Dyspnoea (difficult or laboured respiration)
  10. Hellp syndrome (life-threatening pregnancy complication)

40-49:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Renal injury (kidney injury)

50-59:

  1. Pericarditis (inflammation of the pericardium)

60+:

  1. Diarrhoea
  2. Renal failure acute (rapid kidney dysfunction)
  3. Hypocalcaemia (levels of calcium in blood serum are abnormally low)
  4. Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
  5. Myalgia (muscle pain)
  6. Overdose
  7. Oxygen saturation decreased
  8. Pyrexia (fever)
  9. Troponin i increased
  10. Vomiting

What are the existing conditions these people have? *

  1. Upper Gastrointestinal Haemorrhage (upper gastrointestinal bleeding): 5 people, 11.11%
  2. Gout (uric acid crystals building up in the body): 5 people, 11.11%
  3. Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 4 people, 8.89%
  4. Peripartum Cardiomyopathy (deterioration in cardiac function presenting typically between the last month of pregnancy and up to five months postpartum): 4 people, 8.89%
  5. Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 4 people, 8.89%
  6. Diabetes: 4 people, 8.89%
  7. Type 2 Diabetes: 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Methyldopa and Clopidogrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methyldopa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Clopidogrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methyldopa and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Clopidogrel and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on methyldopa and clopidogrel (the active ingredients of Methyldopa and Clopidogrel, respectively), and Methyldopa and Clopidogrel (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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