Methylfolate and Colace drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylfolate (folic acid) and Colace (docusate ). Common drug interactions include nervous system disorder among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Methylfolate and Colace. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Methylfolate?

Methylfolate has active ingredients of folic acid. eHealthMe is studying from 1,018 Methylfolate users. Check the latest studies of Methylfolate.

What is Colace?

Colace has active ingredients of docusate . It is often used in constipation. eHealthMe is studying from 41,841 Colace users. Check the latest studies of Colace.



On Jul, 24, 2026

17 people who take Methylfolate and Colace together, and have interactions are studied.

Methylfolate and Colace drug interactions.

What are the common drug interactions of Methylfolate and Colace, by gender? *:

female:

  1. Nervous system disorder (a general class of medical conditions affecting the nervous system)
  2. Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)
  3. Neuropathy peripheral (surface nerve damage)
  4. Protein total decreased
  5. Pruritus (severe itching of the skin)
  6. Red blood cell count decreased
  7. Relapsing-remitting multiple sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged)
  8. Skin turgor decreased (less elasticity of skin)
  9. Urinary incontinence (inability to control the flow of urine and involuntary urination)
  10. Urine output decreased

male:

  1. Anaemia (lack of blood)
  2. Aura
  3. Haemoglobin decreased
  4. Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
  5. Hypoacusis (loss of hearing)
  6. Intestinal perforation (complete penetration of the wall of the intestine)
  7. Neuropathy peripheral (surface nerve damage)
  8. Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
  9. Platelet count increased
  10. Polyp

What are the common drug interactions of Methylfolate and Colace, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Secretion discharge
  2. White blood cell count increased
  3. Blood albumin decreased
  4. Blood alkaline phosphatase increased
  5. Blood chloride decreased
  6. Carbon dioxide increased
  7. Haematocrit decreased
  8. Haemoglobin decreased
  9. Platelet count increased
  10. Procalcitonin increased

40-49:

n/a

50-59:

  1. Gait disturbance
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Anxiety
  4. Back pain
  5. Blood pressure decreased
  6. Depression
  7. Emotional distress
  8. Foot fracture
  9. Multiple fractures
  10. Osteoporosis (bones weak and more likely to break)

60+:

  1. Oedema (fluid collection in tissue)
  2. Restless legs syndrome (a powerful urge to move your legs)
  3. Depressed mood
  4. Dysarthria (speech disorder)
  5. Glomerular filtration rate decreased
  6. Hand deformity
  7. Herpes zoster
  8. Influenza
  9. Joint range of motion decreased (disease of joint movement)
  10. Joint swelling

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 17.65%
  2. Pain: 3 people, 17.65%
  3. Diarrhea: 3 people, 17.65%
  4. Muscle Aches (muscle pain): 2 people, 11.76%
  5. Sleep Disorder: 2 people, 11.76%
  6. Chest Pain: 2 people, 11.76%
  7. Depression: 2 people, 11.76%
  8. Nausea (feeling of having an urge to vomit): 2 people, 11.76%
  9. Stress And Anxiety: 2 people, 11.76%
  10. Hiv Infection: 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

Do you take Methylfolate and Colace?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Methylfolate and Colace:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methylfolate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Colace:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methylfolate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Colace and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on folic acid and docusate (the active ingredients of Methylfolate and Colace, respectively), and Methylfolate and Colace (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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