Methylfolate and Vitamin d3 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylfolate (folic acid) and Vitamin d3 (cholecalciferol). Common drug interactions include muscle spasticity among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Methylfolate and Vitamin d3. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Methylfolate?

Methylfolate has active ingredients of folic acid. eHealthMe is studying from 1,018 Methylfolate users. Check the latest studies of Methylfolate.

What is Vitamin d3?

Vitamin d3 has active ingredients of cholecalciferol. It is often used in heart health. eHealthMe is studying from 32,171 Vitamin d3 users. Check the latest studies of Vitamin d3.

On Jul, 16, 2026

29 people who take Methylfolate and Vitamin d3 together, and have interactions are studied.

Methylfolate and Vitamin d3 drug interactions.

What are the common drug interactions of Methylfolate and Vitamin D3, by gender? *:

female:

Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Myelitis transverse (a neurological condition consisting of an inflammatory process of the spinal cord)
Myelopathy (any neurologic deficit related to the spinal cord)
Nervousness
Neuralgia (pain in one or more nerves)
Night sweats (sweating in night)
Nightmare (unpleasant dream)
Nystagmus (a condition of involuntary eye movement)
Oedema (fluid collection in tissue)
Panic attack

male:

Anxiety
Depression
Drug ineffective
Fatigue (feeling of tiredness)
Irritable bowel syndrome
Lethargy (tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight decreased
Headache (pain in head)

What are the common drug interactions of Methylfolate and Vitamin D3, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Haemorrhage (bleeding)
Herpes zoster
Muscle spasms (muscle contraction)
Post herpetic neuralgia (neuralgia caused by the varicella zoster virus)
Uterine pain

30-39:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Abasia (inability to walk)
Anxiety
Blood pressure increased
Hypoaesthesia (reduced sense of touch or sensation)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Muscular weakness (muscle weakness)
Nervousness
Panic attack
Sleep paralysis (waking up and unable to move or speak)

40-49:

Alanine aminotransferase increased
Arthralgia (joint pain)
Aspartate aminotransferase increased
Cardiac disorder
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Cerebral artery embolism (sudden blocking of an artery by a clot or foreign material)
Cerebral cyst (fluid filled tumour of brain)
Depression
Epstein-barr virus infection
Headache (pain in head)

50-59:

Headache (pain in head)
Anger
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Chondropathy (disease of the cartilage)
Drug effect decreased
Drug ineffective
Lethargy (tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Pulmonary thrombosis (scarring in the lungs)
Suicidal ideation

60+:

Depression
Anxiety
Pain
Abdominal discomfort
Abdominal distension
Abdominal pain upper
Apathy
Ataxia (loss of full control of bodily movements)
Blood pressure increased
Burning sensation

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 20.69%
Depression: 6 people, 20.69%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 13.79%
Stress And Anxiety: 3 people, 10.34%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 10.34%
Weight Loss: 2 people, 6.90%
Pain: 2 people, 6.90%
Osteoporosis (bones weak and more likely to break): 2 people, 6.90%
Neuropathy Peripheral (surface nerve damage): 2 people, 6.90%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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