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Methylphenidate hydrochloride and Epidiolex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate hydrochloride (methylphenidate hydrochloride) and Epidiolex (cannabidiol). Common drug interactions include agitation among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate hydrochloride and Epidiolex. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate hydrochloride?

Methylphenidate hydrochloride has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 6,822 Methylphenidate hydrochloride users. Check the latest studies of Methylphenidate hydrochloride.

What is Epidiolex?

Epidiolex has active ingredients of cannabidiol. eHealthMe is studying from 18,763 Epidiolex users. Check the latest studies of Epidiolex.

On Jul, 13, 2026

11 people who take Methylphenidate hydrochloride and Epidiolex together, and have interactions are studied.

Methylphenidate hydrochloride and Epidiolex drug interactions.

What are the common drug interactions of Methylphenidate Hydrochloride and Epidiolex, by gender? *:

female:

  1. Agitation (state of anxiety or nervous excitement)
  2. Anger
  3. Decreased appetite
  4. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  5. Sinusitis (inflammation of sinus)
  6. Weight decreased

male:

  1. Diarrhoea
  2. Headache (pain in head)

What are the common drug interactions of Methylphenidate Hydrochloride and Epidiolex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Diarrhoea
  2. Headache (pain in head)

10-19:

n/a

20-29:

n/a

30-39:

  1. Agitation (state of anxiety or nervous excitement)
  2. Anger
  3. Decreased appetite
  4. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  5. Sinusitis (inflammation of sinus)
  6. Weight decreased

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 3 people, 27.27%
  2. Idiopathic Generalised Epilepsy (epileptic disorders that are believed to have a strong underlying genetic basis): 2 people, 18.18%
  3. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate hydrochloride and Epidiolex?

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Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Methylphenidate hydrochloride and Epidiolex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methylphenidate hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Epidiolex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methylphenidate hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Epidiolex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride and cannabidiol (the active ingredients of Methylphenidate hydrochloride and Epidiolex, respectively), and Methylphenidate hydrochloride and Epidiolex (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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