Methylphenidate hydrochloride and Oxycodone hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate hydrochloride (methylphenidate hydrochloride) and Oxycodone hydrochloride (oxycodone hydrochloride). Common drug interactions include headache among females and drug abuse among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate hydrochloride and Oxycodone hydrochloride. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate hydrochloride?

Methylphenidate hydrochloride has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 6,822 Methylphenidate hydrochloride users. Check the latest studies of Methylphenidate hydrochloride.

What is Oxycodone hydrochloride?

Oxycodone hydrochloride has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 36,817 Oxycodone hydrochloride users. Check the latest studies of Oxycodone hydrochloride.

On Jul, 18, 2026

33 people who take Methylphenidate hydrochloride and Oxycodone hydrochloride together, and have interactions are studied.

Methylphenidate hydrochloride and Oxycodone hydrochloride drug interactions.

What are the common drug interactions of Methylphenidate Hydrochloride and Oxycodone Hydrochloride, by gender? *:

female:

Headache (pain in head)
Dizziness
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Arthralgia (joint pain)
Chills (felling of cold)
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Confusional state
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

male:

Drug abuse
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Bone density decreased
Death
Emotional distress
Fracture
Haemoglobin decreased
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Methylphenidate Hydrochloride and Oxycodone Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug abuse
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

20-29:

n/a

30-39:

Drug abuse
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Overdose
Drug dependence
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Poisoning
Pulmonary embolism (blockage of the main artery of the lung)
Abdominal distension
Anaemia of chronic disease

40-49:

Abdominal discomfort
Death
Diarrhoea
Drug abuse
Eructation (release of gas from the digestive tract)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

50-59:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug diversion
Flushing (the warm, red condition of human skin)
Hyperhidrosis (abnormally increased sweating)

60+:

Dizziness
Headache (pain in head)
Death
Diarrhoea
Flatulence (flatus expelled through the anus)
Full blood count decreased
Haemoglobin decreased
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 9.09%
Multiple Myeloma (cancer of the plasma cells): 3 people, 9.09%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 6.06%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 2 people, 6.06%
Depression: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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