Methylphenidate hydrochloride and Plavix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate hydrochloride (methylphenidate hydrochloride) and Plavix (clopidogrel bisulfate). Common drug interactions include renal failure among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate hydrochloride and Plavix. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate hydrochloride?

Methylphenidate hydrochloride has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 6,822 Methylphenidate hydrochloride users. Check the latest studies of Methylphenidate hydrochloride.

What is Plavix?

Plavix has active ingredients of clopidogrel bisulfate. It is often used in stent. eHealthMe is studying from 151,178 Plavix users. Check the latest studies of Plavix.



On Jul, 07, 2026

15 people who take Methylphenidate hydrochloride and Plavix together, and have interactions are studied.

Methylphenidate hydrochloride and Plavix drug interactions.

What are the common drug interactions of Methylphenidate Hydrochloride and Plavix, by gender? *:

female:

  1. Renal failure (kidney dysfunction)
  2. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  3. Renal impairment (severely reduced kidney function)
  4. Renal injury (kidney injury)
  5. Anxiety
  6. Carotid artery stenosis (narrowing of carotid artery)
  7. Depression
  8. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  9. Migraine (headache)
  10. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

male:

  1. Pneumonia
  2. Back pain
  3. Diplopia (double vision)
  4. Haemorrhagic cyst (bleeding cyst)
  5. Headache (pain in head)
  6. Hydrocephalus (water on the brain)
  7. Neoplasm progression (growth of tumour)
  8. Parinaud syndrome (dorsal midbrain syndrome)
  9. Pulmonary embolism (blockage of the main artery of the lung)
  10. Renal failure acute (rapid kidney dysfunction)

What are the common drug interactions of Methylphenidate Hydrochloride and Plavix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Gastric haemorrhage (bleeding stomach)
  2. Vomiting

20-29:

n/a

30-39:

  1. Carotid artery stenosis (narrowing of carotid artery)

40-49:

  1. Respiratory rate increased (excess breathing rate/min)
  2. Respiratory tract infection
  3. Respiratory tract infection fungal
  4. Sputum retention
  5. Suicidal ideation
  6. Tremor (trembling or shaking movements in one or more parts of your body)
  7. Vision blurred
  8. Vomiting
  9. Weight decreased
  10. Wheezing (a high-pitched whistling sound made while you breath)

50-59:

  1. Cardiac failure
  2. Colon cancer
  3. Depressed level of consciousness
  4. Diplopia (double vision)
  5. Haemorrhagic cyst (bleeding cyst)
  6. Headache (pain in head)
  7. Hydrocephalus (water on the brain)
  8. Neoplasm progression (growth of tumour)
  9. Parinaud syndrome (dorsal midbrain syndrome)
  10. Pneumonia

60+:

  1. Chronic kidney disease
  2. Death
  3. Blood pressure diastolic decreased
  4. Cough
  5. Decreased interest
  6. Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  7. Dysarthria (speech disorder)
  8. Dysphagia (a condition in which swallowing is difficult or painful)
  9. Facial paralysis (loss of function of face muscle)
  10. Fall

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 20.00%
  2. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 20.00%
  3. High Blood Pressure: 3 people, 20.00%
  4. Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 13.33%
  5. Stress And Anxiety: 2 people, 13.33%
  6. Multiple Myeloma (cancer of the plasma cells): 2 people, 13.33%
  7. Wound: 1 person, 6.67%
  8. Conjunctivitis (pink eye): 1 person, 6.67%
  9. Colon Cancer: 1 person, 6.67%
  10. Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Methylphenidate hydrochloride and Plavix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methylphenidate hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Plavix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methylphenidate hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Plavix and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride and clopidogrel bisulfate (the active ingredients of Methylphenidate hydrochloride and Plavix, respectively), and Methylphenidate hydrochloride and Plavix (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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