Methylphenidate hydrochloride and Zonisamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate hydrochloride (methylphenidate hydrochloride) and Zonisamide (zonisamide). Common drug interactions include transient ischaemic attack among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate hydrochloride and Zonisamide. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate hydrochloride?

Methylphenidate hydrochloride has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 6,822 Methylphenidate hydrochloride users. Check the latest studies of Methylphenidate hydrochloride.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

On Jul, 30, 2026

19 people who take Methylphenidate hydrochloride and Zonisamide together, and have interactions are studied.

Methylphenidate hydrochloride and Zonisamide drug interactions.

What are the common drug interactions of Methylphenidate Hydrochloride and Zonisamide, by gender? *:

female:

Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Confusional arousal (behaviours that occur around sleep)
Facial paralysis (loss of function of face muscle)
Fine motor delay (delayed movements and actions of the muscles)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Confusional state
Acne (skin problems that cause pimples)
Suicidal ideation
Calculus urinary (stone in urinary system)

male:

Drug ineffective
Dyschezia (difficulty in defecating)
Prostate cancer

What are the common drug interactions of Methylphenidate Hydrochloride and Zonisamide, by age (0-1 to 60+)? *:

0-1:

Drug ineffective

2-9:

Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood lactate dehydrogenase increased
C-reactive protein increased
Eosinophil count increased
Erythema multiforme (a type of hypersensitivity reaction)
Gamma-glutamyltransferase increased
Human herpes virus 6 serology positive
Lymphadenopathy (disease or enlargement of lymph nodes)
Lymphocyte stimulation test positive

10-19:

n/a

20-29:

n/a

30-39:

Confusional state
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Insomnia (sleeplessness)
Night sweats (sweating in night)
Oral herpes (viral infection of mouth)
Restless legs syndrome (a powerful urge to move your legs)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnambulism (sleep walking)
Tardive dyskinesia (a disorder that involves involuntary movements)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

40-49:

Peripheral nerve lesion
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Calculus urinary (stone in urinary system)
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Intervertebral disc displacement
Mass
Nasopharyngitis (inflammation of the nasopharynx)
Paraplegia (paralysis of the legs and lower body)

50-59:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Flushing (the warm, red condition of human skin)
Hyperhidrosis (abnormally increased sweating)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 42.11%
Drowsiness: 7 people, 36.84%
Bipolar Disorder (mood disorder): 7 people, 36.84%
Restless Leg Syndrome (a powerful urge to move your legs): 5 people, 26.32%
Rapid Eye Movements Sleep Abnormal: 5 people, 26.32%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 26.32%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 15.79%
Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 3 people, 15.79%
Infantile Spasms: 2 people, 10.53%
Idiopathic Generalised Epilepsy (epileptic disorders that are believed to have a strong underlying genetic basis): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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