Methylphenidate and Effexor xr drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate (methylphenidate) and Effexor xr (venlafaxine hydrochloride). Common drug interactions include dizziness among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate and Effexor xr. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Effexor xr?

Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 35,233 Effexor xr users. Check the latest studies of Effexor xr.

On Jul, 10, 2026

14 people who take Methylphenidate and Effexor xr together, and have interactions are studied.

Methylphenidate and Effexor xr drug interactions.

What are the common drug interactions of Methylphenidate and Effexor Xr, by gender? *:

female:

Dizziness
Drug dependence
Suicidal ideation
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Hypoacusis (loss of hearing)
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
Cataract (clouding of the lens inside the eye)
Headache (pain in head)
Weight decreased
Abnormal loss of weight

male:

Hypotension (abnormally low blood pressure)
Body height decreased
Osteoporosis (bones weak and more likely to break)
Pain
Spinal compression fracture (fracture due to spinal compression on bone)
Spinal fracture (fracture in one of vertebrae)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Multiple system atrophy (degeneration of nerve cells in specific areas of the brain)
Nasopharyngitis (inflammation of the nasopharynx)

What are the common drug interactions of Methylphenidate and Effexor Xr, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abnormal loss of weight
Arthralgia (joint pain)
Blood creatine phosphokinase increased
Device related infection
Headache (pain in head)
Hypertension (high blood pressure)
Influenza
Infusion site infection
Lymphadenopathy (disease or enlargement of lymph nodes)
Malaise (a feeling of general discomfort or uneasiness)

40-49:

Hypotension (abnormally low blood pressure)
Nasopharyngitis (inflammation of the nasopharynx)

50-59:

Cataract (clouding of the lens inside the eye)
Dizziness
Drug dependence
Nausea (feeling of having an urge to vomit)
Suicidal ideation
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Hypoacusis (loss of hearing)
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)

60+:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Hypotension (abnormally low blood pressure)
Multiple system atrophy (degeneration of nerve cells in specific areas of the brain)

What are the existing conditions these people have? *

Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 6 people, 42.86%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 6 people, 42.86%
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 2 people, 14.29%
Pain: 2 people, 14.29%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 14.29%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 7.14%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 1 person, 7.14%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 1 person, 7.14%
Iga Nephropathy (kidney disease- condition prevents the kidneys from filtering waste): 1 person, 7.14%
Hypotension (abnormally low blood pressure): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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