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Methotrexate and Mean cell haemoglobin concentration increased - a phase IV clinical study of FDA data

Summary:

Mean cell haemoglobin concentration increased is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Omeprazole, and have Crohn's disease.

The phase IV clinical study analyzes which people have Mean cell haemoglobin concentration increased when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Mean cell haemoglobin concentration increased?

Mean cell haemoglobin concentration increased (more concentration of haemoglobin in a given volume of packed red blood cells) is found to be associated with 132 drugs and 241 conditions by eHealthMe. Check the latest studies of Mean cell haemoglobin concentration increased.

On Jul, 10, 2026

599,650 people reported to have side effects when taking Methotrexate.
Among them, 19 people (0.0%) have Mean cell haemoglobin concentration increased.

Could Methotrexate cause Mean cell haemoglobin concentration increased?

Among these 19 people:

How long have people been on Methotrexate when they have Mean cell haemoglobin concentration increased? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 50 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Mean cell haemoglobin concentration increased when taking Methotrexate? *

  • female: 68.75 %
  • male: 31.25 %

What is the age of people who have Mean cell haemoglobin concentration increased when taking Methotrexate? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 6.67 %
  • 20-29: 6.67 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 73.33 %
  • 60+: 13.33 %

What are other drugs people take besides Methotrexate? *

  1. Fluconazole: 4 people, 21.05%
  2. Folic Acid: 4 people, 21.05%
  3. Humira: 4 people, 21.05%
  4. Omeprazole: 4 people, 21.05%
  5. Enbrel: 3 people, 15.79%
  6. Inflectra: 3 people, 15.79%
  7. Fexofenadine Hydrochloride: 2 people, 10.53%
  8. Ondansetron: 2 people, 10.53%
  9. Nystatin: 2 people, 10.53%
  10. Nizatidine: 2 people, 10.53%

What are other side effects people have besides Mean cell haemoglobin concentration increased? *

  1. Red Blood Cell Count Decreased: 11 people, 57.89%
  2. Haemoglobin Decreased: 8 people, 42.11%
  3. Weight Decreased: 8 people, 42.11%
  4. Haematocrit Decreased: 8 people, 42.11%
  5. International Normalised Ratio Increased: 7 people, 36.84%
  6. Transaminases Increased: 7 people, 36.84%
  7. Lymphocyte Count Increased: 6 people, 31.58%
  8. Body Temperature Fluctuation: 6 people, 31.58%
  9. Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 6 people, 31.58%
  10. Oxygen Saturation Abnormal: 6 people, 31.58%

What are the existing conditions these people have? *

  1. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 31.58%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 21.05%
  3. Rhinorrhea (watery mucus discharge from the nose): 2 people, 10.53%
  4. Ill-Defined Disorder: 2 people, 10.53%
  5. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 5.26%
  6. Psoriasis (immune-mediated disease that affects the skin): 1 person, 5.26%
  7. Nausea (feeling of having an urge to vomit): 1 person, 5.26%
  8. Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 1 person, 5.26%
  9. Joint Pain: 1 person, 5.26%
  10. Inflammatory Bowel Disease: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Mean cell haemoglobin concentration increased?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Mean cell haemoglobin concentration increased treatments and more:

How severe was Mean cell haemoglobin concentration increased and when was it recovered:

Expand to all the drugs that have ingredients of methotrexate sodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mean cell haemoglobin concentration increased:

Browse all the conditions that are associated with Mean cell haemoglobin concentration increased:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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