Methylphenidate and Epinephrine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate (methylphenidate) and Epinephrine (epinephrine). Common drug interactions include drug hypersensitivity among females and lymphadenopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate and Epinephrine. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Epinephrine?

Epinephrine has active ingredients of epinephrine. It is often used in asthma. eHealthMe is studying from 21,290 Epinephrine users. Check the latest studies of Epinephrine.

On Jul, 19, 2026

92 people who take Methylphenidate and Epinephrine together, and have interactions are studied.

Methylphenidate and Epinephrine drug interactions.

What are the common drug interactions of Methylphenidate and Epinephrine, by gender? *:

female:

Drug hypersensitivity
Dysphagia (a condition in which swallowing is difficult or painful)
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Infusion site pain
Infusion site swelling
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Urinary tract infection

male:

Lymphadenopathy (disease or enlargement of lymph nodes)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Pruritus (severe itching of the skin)
Surgery
Sleep disorder
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Ear infection
Injection site pain
Injection site pruritus (severe itching at injection site)
Injection site swelling

What are the common drug interactions of Methylphenidate and Epinephrine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Lymphadenopathy (disease or enlargement of lymph nodes)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Precocious puberty
Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)
Surgery
Anxiety
Dyskinesia (abnormality or impairment of voluntary movement)
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Diarrhoea
Dysphonia (speech disorder attributable to a disorder of phonation)

10-19:

Weight decreased
Sleep disorder
Nausea (feeling of having an urge to vomit)
Syncope (loss of consciousness with an inability to maintain postural tone)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Discomfort
Eye irritation
Ocular hyperaemia (an abnormally large amount of blood in eye)
Oropharyngeal pain
Rash

20-29:

Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Discomfort
Rash
Infection
Injection site reaction
Insomnia (sleeplessness)
Lip swelling
Cough
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Sinusitis (inflammation of sinus)

30-39:

Pain
Abnormal loss of weight
Arthralgia (joint pain)
Blood creatine phosphokinase increased
Device related infection
Headache (pain in head)
Hypertension (high blood pressure)
Influenza
Infusion site infection
Lymphadenopathy (disease or enlargement of lymph nodes)

40-49:

Anxiety
Chills (felling of cold)
Diarrhoea
Dry skin
Dysarthria (speech disorder)
Dysphagia (a condition in which swallowing is difficult or painful)
Eyelid ptosis (falling of the upper or lower eyelid)
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Malaise (a feeling of general discomfort or uneasiness)

50-59:

Feeling cold
Feeling hot
Fibromyalgia (a long-term condition which causes pain all over the body)
Flushing (the warm, red condition of human skin)
Gallbladder mucocoele (obstruction of the gallbladder's storage capacity due to the formation of a thick, mucoid bile mass inside the gallbladder)
Hallucination (an experience involving the perception of something not present)
Headache (pain in head)
Heart rate increased
Hepatic steatosis (fatty liver disease)
Influenza

60+:

Cough
Pruritus (severe itching of the skin)
Infusion site swelling
Peripheral swelling
Sinusitis (inflammation of sinus)
Hypersensitivity
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Dysphonia (speech disorder attributable to a disorder of phonation)
Infusion site pain
Infusion site pruritus (severe itching at infusion site)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 26 people, 28.26%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 18 people, 19.57%
Drowsiness: 16 people, 17.39%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 16 people, 17.39%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 16 people, 17.39%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 5 people, 5.43%

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate and Epinephrine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously