Methylphenidate and Estradiol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate (methylphenidate) and Estradiol (estradiol). Common drug interactions include drug ineffective among females and electrocardiogram qt prolonged among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate and Estradiol. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Estradiol?

Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,986 Estradiol users. Check the latest studies of Estradiol.

On Jul, 15, 2026

49 people who take Methylphenidate and Estradiol together, and have interactions are studied.

Methylphenidate and Estradiol drug interactions.

What are the common drug interactions of Methylphenidate and Estradiol, by gender? *:

female:

Drug ineffective
Arthralgia (joint pain)
Sleep disorder
Weight increased
Asthma
Breast tenderness
Decreased appetite
Fluid retention (an abnormal accumulation of fluid in the blood)
Gait disturbance
Gingival disorder (gum disease)

male:

Electrocardiogram qt prolonged

What are the common drug interactions of Methylphenidate and Estradiol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Electrocardiogram qt prolonged
Intestinal obstruction

30-39:

Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Drug ineffective
Fungal infection
Nerve injury
Pain
Urinary tract infection
Ear infection
Insomnia (sleeplessness)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Ovarian cyst (fluid filled sac of the ovary)

40-49:

Anxiety
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Femoroacetabular impingement (a condition affecting the hip joint in young and middle-aged adults)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Post procedural infection
Allodynia (a condition in which pain is caused by a stimulus that does not normally elicit pain)
Arthralgia (joint pain)
Mobility decreased (ability to move is reduced)
Skin burning sensation
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

50-59:

Throat irritation
Throat tightness
Vertigo
Visual impairment
White blood cell count decreased
Anaemia (lack of blood)
Application site erythema (redness of the skin at application site)
Balance disorder
Blood pressure increased
Diarrhoea

60+:

Drug ineffective
Hypersensitivity
Depression
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal bacterial infection (infection of the stomach and intestines caused by bacteria)
Gingival disorder (gum disease)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Immunisation reaction
Lymphadenopathy (disease or enlargement of lymph nodes)
Lymphatic disorder (disease of lymphatic system)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 18 people, 36.73%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 30.61%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 10.20%
Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 5 people, 10.20%
Drowsiness: 5 people, 10.20%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 8.16%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 6.12%
Pain: 3 people, 6.12%
Insomnia (sleeplessness): 3 people, 6.12%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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