Methylphenidate and Evekeo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate (methylphenidate) and Evekeo (amphetamine sulfate). Common drug interactions include hepatic cirrhosis among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate and Evekeo. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Evekeo?

Evekeo has active ingredients of amphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 575 Evekeo users. Check the latest studies of Evekeo.

On Jul, 18, 2026

15 people who take Methylphenidate and Evekeo together, and have interactions are studied.

Methylphenidate and Evekeo drug interactions.

What are the common drug interactions of Methylphenidate and Evekeo, by gender? *:

female:

Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Obesity (having too much body fat)
Dyspnoea (difficult or laboured respiration)
Blood urine present
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Protein urine
Urinary tract infection
Gastric bypass

male:

Fall
Migraine (headache)
Pain
Blood pressure increased
Hypertension (high blood pressure)

What are the common drug interactions of Methylphenidate and Evekeo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Idiopathic intracranial hypertension (elevated cerebrospinal fluid pressure of unknown cause)

30-39:

Fall
Migraine (headache)
Pain
Blood pressure increased
Hypertension (high blood pressure)

40-49:

Blood urine present
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Protein urine
Urinary tract infection

50-59:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Dyspnoea (difficult or laboured respiration)
Gastric bypass
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Anxiety
Back pain
Bladder disorder
Depression
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Renal disorder (kidney disease)

60+:

Joint injury
Surgery

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 100.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 53.33%
Drowsiness: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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