Methylphenidate and Zantac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate (methylphenidate) and Zantac (ranitidine hydrochloride). Common drug interactions include blood pressure systolic increased among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate and Zantac. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

On Jul, 26, 2026

75 people who take Methylphenidate and Zantac together, and have interactions are studied.

Methylphenidate and Zantac drug interactions.

What are the common drug interactions of Methylphenidate and Zantac, by gender? *:

female:

Blood pressure systolic increased
Body temperature increased
Cardiac arrest
Death
Diplopia (double vision)
Dry eye (lack of adequate tears)
Dry mouth
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)
Effusion (an escape of fluid into a body cavity)

male:

Constipation
Pneumonia
Haemoglobin increased
Rhinorrhoea (watery mucus discharge from the nose)
Tympanic membrane scarring (scar formation on ear drum)
Vitamin d deficiency
Weight gain poor
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Parkinson's disease
Abdominal pain

What are the common drug interactions of Methylphenidate and Zantac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

10-19:

Pneumonia
Dizziness
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Abdominal pain
Affective disorder (mental disorder)
Anxiety
Back pain
Chest pain
Constipation
Depressive symptom

20-29:

Fatigue (feeling of tiredness)
Headache (pain in head)
Insomnia (sleeplessness)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Restless legs syndrome (a powerful urge to move your legs)

30-39:

Surgery
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tendonitis (a condition that causes pain and swelling of tendons)
Tongue ulceration (ulcers on tongue)
Toothache (tooth pain)
Viral myocarditis (inflammation of heart muscle caused by viral infection)
White blood cell count increased
Blood pressure increased
Weight decreased
Blood pressure diastolic increased

40-49:

Anxiety
Chronic kidney disease
Renal failure (kidney dysfunction)
Depression
Renal disorder (kidney disease)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Syncope (loss of consciousness with an inability to maintain postural tone)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Nephropathy (damage to or disease of a kidney)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Contusion (a type of hematoma of tissue in which capillaries)
Haematocrit increased
Joint swelling
Pruritus (severe itching of the skin)
Rash
Red blood cell count increased
Organ failure

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Vision blurred
Blindness
Death
Diplopia (double vision)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 37 people, 49.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 25 people, 33.33%
Pain: 9 people, 12.00%
Muscle Spasms (muscle contraction): 6 people, 8.00%
Depression: 6 people, 8.00%
Cystic Fibrosis (disease of the secretary glands): 6 people, 8.00%
Wheezing (a high-pitched whistling sound made while you breath): 5 people, 6.67%
Infection: 5 people, 6.67%
High Blood Pressure: 5 people, 6.67%
Pneumonia: 4 people, 5.33%

* Approximation only. Some reports may have incomplete information.

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