Methylphenidate and Zomig drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate (methylphenidate) and Zomig (zolmitriptan). Common drug interactions include staphylococcal infection among females and psoriatic arthropathy among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate and Zomig. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Zomig?

Zomig has active ingredients of zolmitriptan. It is often used in migraine. eHealthMe is studying from 7,356 Zomig users. Check the latest studies of Zomig.



On Jul, 21, 2026

29 people who take Methylphenidate and Zomig together, and have interactions are studied.

Methylphenidate and Zomig drug interactions.

What are the common drug interactions of Methylphenidate and Zomig, by gender? *:

female:

  1. Staphylococcal infection (an infection with staphylococcus bacteria)
  2. Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
  3. Somnolence (a state of near-sleep, a strong desire for sleep)
  4. Tremor (trembling or shaking movements in one or more parts of your body)
  5. Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
  6. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  7. Addison's disease (addison's disease, a hormonal disorder disease)
  8. Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones)
  9. Blood cholesterol increased
  10. Bone pain

male:

  1. Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

What are the common drug interactions of Methylphenidate and Zomig, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Cardiovascular disorder (heart diseases)

30-39:

  1. Suicidal ideation
  2. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  3. Enuresis (repeated inability to control urination)
  4. Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
  5. Somnolence (a state of near-sleep, a strong desire for sleep)
  6. Tremor (trembling or shaking movements in one or more parts of your body)
  7. Hospitalisation
  8. Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
  9. Rash

40-49:

  1. Abnormal behaviour
  2. Blood pressure increased
  3. Post-traumatic stress disorder
  4. Staphylococcal infection (an infection with staphylococcus bacteria)
  5. Victim of sexual abuse
  6. Weight decreased
  7. Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
  8. Enuresis (repeated inability to control urination)
  9. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  10. Urinary tract infection

50-59:

  1. Bone pain
  2. Fall
  3. Respiratory syncytial virus infection (viral disease of respiratory system)
  4. Toothache (tooth pain)
  5. Vertigo
  6. Fungal sepsis (whole body infection by fungus)
  7. Nephrolithiasis (calculi in the kidneys)
  8. Renal cancer (cancer of kidney)
  9. Renal failure (kidney dysfunction)
  10. Renal neoplasm (kidney tumour)

60+:

n/a

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 22 people, 75.86%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 37.93%
  3. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 13.79%
  4. Drowsiness: 4 people, 13.79%
  5. Muscle Spasms (muscle contraction): 3 people, 10.34%
  6. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate and Zomig?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Methylphenidate and Zomig:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methylphenidate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zomig:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methylphenidate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zomig and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate and zolmitriptan (the active ingredients of Methylphenidate and Zomig, respectively), and Methylphenidate and Zomig (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: