Methylprednisolone and Hydrocortone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylprednisolone (methylprednisolone) and Hydrocortone (hydrocortisone acetate). Common drug interactions include cough among females and diaphragmatic paralysis among males.

The phase IV clinical study analyzes what interactions people have when they take Methylprednisolone and Hydrocortone. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Methylprednisolone?

Methylprednisolone has active ingredients of methylprednisolone. It is often used in inflammation. eHealthMe is studying from 59,645 Methylprednisolone users. Check the latest studies of Methylprednisolone.

What is Hydrocortone?

Hydrocortone has active ingredients of hydrocortisone acetate. It is often used in pain. eHealthMe is studying from 912 Hydrocortone users. Check the latest studies of Hydrocortone.

On Jul, 06, 2026

17 people who take Methylprednisolone and Hydrocortone together, and have interactions are studied.

Methylprednisolone and Hydrocortone drug interactions.

What are the common drug interactions of Methylprednisolone and Hydrocortone, by gender? *:

female:

Cough
Chest pain
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Renal failure acute (rapid kidney dysfunction)
Respiratory distress (difficulty in breathing)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Dyspnoea paroxysmal nocturnal (respiratory distress that awakens patients from sleep)
Orthopnoea (shortness of breath (dyspnea) when lying down)
Pulmonary embolism (blockage of the main artery of the lung)

male:

Diaphragmatic paralysis (acquired dysfunction of the phrenic nerve)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Death
Diarrhoea
Disease recurrence
Erythema (redness of the skin)
Infusion related reaction
Lung infection
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Necrosis (the death of body tissue)

What are the common drug interactions of Methylprednisolone and Hydrocortone, by age (0-1 to 60+)? *:

0-1:

Agitation (state of anxiety or nervous excitement)
Diarrhoea
Disease recurrence
Erythema (redness of the skin)
Infusion related reaction
Lung infection
Pyrexia (fever)
Rash erythematous (redness of the skin)
Wheezing (a high-pitched whistling sound made while you breath)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chest pain
Cough
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Dyspnoea paroxysmal nocturnal (respiratory distress that awakens patients from sleep)
Orthopnoea (shortness of breath (dyspnea) when lying down)
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary infarction (death of a small area of lung)
Thrombosis (formation of a blood clot inside a blood vessel)

50-59:

Death
Neutropenia (an abnormally low number of neutrophils)
Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Renal failure acute (rapid kidney dysfunction)
Productive cough
Rash
Secondary adrenocortical insufficiency (inadequate secretion of acth by the pituitary gland)
Stress cardiomyopathy (stress-induced chronic disease of the heart muscle)
Thyroiditis (inflammation of thyroid gland)
Acute respiratory distress syndrome
Chest pain
Drug ineffective

What are the existing conditions these people have? *

Aplastic Anemia: 4 people, 23.53%
Stress And Anxiety: 3 people, 17.65%
Depression: 3 people, 17.65%
Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 2 people, 11.76%
Thyrotoxic Crisis (a life threatening condition due to excess secretion of thyroid hormone): 1 person, 5.88%
Sedation: 1 person, 5.88%
Oedema (fluid collection in tissue): 1 person, 5.88%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 1 person, 5.88%
Metastases To Lung (cancer spreads to lung): 1 person, 5.88%
Infection: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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