Metolazone and Abilify drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metolazone (metolazone) and Abilify (aripiprazole). Common drug interactions include chronic kidney disease among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Metolazone and Abilify. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Metolazone?

Metolazone has active ingredients of metolazone. It is often used in swelling. eHealthMe is studying from 13,411 Metolazone users. Check the latest studies of Metolazone.

What is Abilify?

Abilify has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 101,454 Abilify users. Check the latest studies of Abilify.

On Jul, 14, 2026

40 people who take Metolazone and Abilify together, and have interactions are studied.

Metolazone and Abilify drug interactions.

What are the common drug interactions of Metolazone and Abilify, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Nephrogenic anaemia (anaemia due to kidney disease)
Glomerulonephritis chronic (long lasting group of conditions that affect parts of the kidneys called glomeruli)
Renal haematoma (blood collection in kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephritic syndrome (a collection of signs (known as a syndrome) associated with disorders affecting the kidneys, more specifically glomerular disorders)
Renal tubular necrosis (death of kidney tubules)
Arthralgia (joint pain)
Death

male:

Cardiac failure congestive
Anxiety
Iron deficiency anaemia
Magnesium deficiency (lack of magnesium)
Chronic kidney disease
Dyspnoea exertional (breathlessness or shortness of breath)
Dystonia (abnormal muscle tone)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Acute respiratory failure
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the common drug interactions of Metolazone and Abilify, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cardiac disorder
Fall
Lung disorder (lung disease)
Malaise (a feeling of general discomfort or uneasiness)
Spinal fracture (fracture in one of vertebrae)
Anxiety
Asthma
Cardiac failure congestive
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

20-29:

n/a

30-39:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Acute left ventricular failure (heart attack)
Acute respiratory failure
Agitation (state of anxiety or nervous excitement)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Chronic left ventricular failure (long lasting functional impairment of left ventricle of heart)
Dyspepsia (indigestion)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Pancreatitis (inflammation of pancreas)
Pleural effusion (water on the lungs)
Prerenal failure

50-59:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Cardiac failure congestive
Glomerulonephritis chronic (long lasting group of conditions that affect parts of the kidneys called glomeruli)
Renal haematoma (blood collection in kidney)
Dyspnoea exertional (breathlessness or shortness of breath)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephritic syndrome (a collection of signs (known as a syndrome) associated with disorders affecting the kidneys, more specifically glomerular disorders)
Pulmonary hypertension (increase in blood pressure in the lung artery)

60+:

Renal failure (kidney dysfunction)
Chronic kidney disease
Thrombocytopenia (decrease of platelets in blood)
Vomiting
Anaemia (lack of blood)
Death
Flatulence (flatus expelled through the anus)
Headache (pain in head)
Hypersensitivity
Influenza like illness

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 37.50%
High Blood Cholesterol: 8 people, 20.00%
High Blood Pressure: 8 people, 20.00%
Pain: 8 people, 20.00%
Stress And Anxiety: 6 people, 15.00%
Blood Pressure Abnormal: 5 people, 12.50%
Sleep Disorder: 5 people, 12.50%
Cardiac Disorder: 5 people, 12.50%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 12.50%
Insomnia (sleeplessness): 4 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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