Mevacor and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mevacor (lovastatin) and Actos (pioglitazone hydrochloride). Common drug interactions include neuropathy peripheral among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Mevacor and Actos. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Mevacor?

Mevacor has active ingredients of lovastatin. It is often used in high blood cholesterol. eHealthMe is studying from 4,988 Mevacor users. Check the latest studies of Mevacor.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 17, 2026

70 people who take Mevacor and Actos together, and have interactions are studied.

What are the common drug interactions of Mevacor and Actos, by gender? *:

female:

Neuropathy peripheral (surface nerve damage)
Palpitations (feelings or sensations that your heart is pounding or racing)
Dehydration (dryness resulting from the removal of water)
Diabetic eye disease
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Meniscus lesion (lesion of a crescent-shaped piece of cartilage between the femur and the tibia)
Panic attack
Post-traumatic stress disorder
Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)

male:

Dyspnoea (difficult or laboured respiration)
Hypertension (high blood pressure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrioventricular block complete (heart block complete)
Blood glucose increased
Bradycardia (abnormally slow heart action)
Cardiomegaly (increased size of heart than normal)
Cough

What are the common drug interactions of Mevacor and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Cataract (clouding of the lens inside the eye)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dehydration (dryness resulting from the removal of water)
Diabetic eye disease
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Hypertension (high blood pressure)
Meniscus lesion (lesion of a crescent-shaped piece of cartilage between the femur and the tibia)
Neuropathy peripheral (surface nerve damage)

40-49:

International normalised ratio increased

50-59:

Cardiovascular disorder (heart diseases)
Chest pain
Dyslipidaemia (abnormal amount of lipids)
Fall
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Haematuria (presence of blood in urine)
Hepatic steatosis (fatty liver disease)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Mitral valve calcification (calcium deposit in mitral valve)

60+:

Dyspnoea (difficult or laboured respiration)
Hypertension (high blood pressure)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrioventricular block complete (heart block complete)
Bradycardia (abnormally slow heart action)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiomegaly (increased size of heart than normal)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

What are the existing conditions these people have? *

Depression: 16 people, 22.86%
High Blood Pressure: 14 people, 20.00%
Stress And Anxiety: 14 people, 20.00%
Bipolar Disorder (mood disorder): 9 people, 12.86%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 11.43%
Type 2 Diabetes: 6 people, 8.57%
Muscle Aches (muscle pain): 6 people, 8.57%
Bacterial Infection: 5 people, 7.14%
Headache (pain in head): 5 people, 7.14%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 5 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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