Microzide and Loraz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Microzide (hydrochlorothiazide) and Loraz (lorazepam). Common drug interactions include hypercalcaemia among females and acute stress disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Microzide and Loraz. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Microzide?

Microzide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 994 Microzide users. Check the latest studies of Microzide.

What is Loraz?

Loraz has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,695 Loraz users. Check the latest studies of Loraz.

On Aug, 05, 2026

28 people who take Microzide and Loraz together, and have interactions are studied.

What are the common drug interactions of Microzide and Loraz, by gender? *:

female:

Hypercalcaemia (elevated calcium (ca+) level in the blood)
Immune system disorder
International normalised ratio increased
Lethargy (tiredness)
Loss of consciousness
Memory impairment
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Muscle cramps (painful sensations caused by muscle contraction)
Myalgia (muscle pain)

male:

Acute stress disorder
Adjustment disorder
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
Chronic kidney disease
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state
Disturbance in attention
Drug ineffective
Encephalopathy (functioning of the brain is affected by some agent or condition)

What are the common drug interactions of Microzide and Loraz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Social problem
Spinal osteoarthritis (joint cartilage loss in spine)
Spondylitis (an inflammation of the vertebra with spinal cord involvement)
Suicidal ideation
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Acute stress disorder
Adjustment disorder
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Back pain
Balance disorder

50-59:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Anosognosia (ignorance of the presence of disease)
Cardiac flutter (abnormal heart rhythm)
Dizziness
Hyperhidrosis (abnormally increased sweating)
Memory impairment
Mood swings (an extreme or rapid change in mood)
Palpitations (feelings or sensations that your heart is pounding or racing)
Tremor (trembling or shaking movements in one or more parts of your body)
Vision blurred

60+:

Bladder cancer stage iv
Chronic kidney disease
Decreased interest
Depressed mood
Fatigue (feeling of tiredness)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hypotension (abnormally low blood pressure)
International normalised ratio increased
Lethargy (tiredness)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 6 people, 21.43%
Insomnia (sleeplessness): 6 people, 21.43%
Pain: 6 people, 21.43%
Constipation: 5 people, 17.86%
High Blood Cholesterol: 4 people, 14.29%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 14.29%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 14.29%
Depression: 3 people, 10.71%
Thyroid Diseases: 3 people, 10.71%
Hypersensitivity: 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

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