Metformin and Dysthymia - a phase IV clinical study of FDA data

Summary:

Dysthymia is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 60+ old, also take Seroquel, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Dysthymia when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Dysthymia?

Dysthymia (mild chronic depression) is found to be associated with 243 drugs and 449 conditions by eHealthMe. Check the latest studies of Dysthymia.

On Apr, 17, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 20 people (0.0%) have Dysthymia.

Among these 20 people:

What is the gender of people who have Dysthymia when taking Metformin? *

female: 75 %
male: 25 %

What is the age of people who have Dysthymia when taking Metformin? *

What are other drugs people take besides Metformin? *

What are other side effects people have besides Dysthymia? *

Back Pain: 10 people, 50.00%
Pneumonia: 9 people, 45.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 8 people, 40.00%
Intervertebral Disc Degeneration (spinal disc degeneration): 8 people, 40.00%
Dizziness: 8 people, 40.00%
Stomatitis (inflammation of mucous membrane of mouth): 6 people, 30.00%
Pain In Jaw: 6 people, 30.00%
Bone Density Decreased: 6 people, 30.00%
Dependent Personality Disorder: 6 people, 30.00%
Fainting (loss of consciousness and postural tone): 6 people, 30.00%

What are the existing conditions these people have? *

Stress And Anxiety: 9 people, 45.00%
Depression: 5 people, 25.00%
Osteoporosis (bones weak and more likely to break): 5 people, 25.00%
Insomnia (sleeplessness): 3 people, 15.00%
Bipolar Disorder (mood disorder): 3 people, 15.00%
Pain: 2 people, 10.00%
Psychotic Disorder: 2 people, 10.00%
Post-Traumatic Stress Disorder: 2 people, 10.00%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 10.00%
Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Dysthymia?

- Check whether Dysthymia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Metformin (465,354 reports)

Dysthymia treatments and more:

Dysthymia (4,904 reports)

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dysthymia:

Dysthymia (243 drugs)

Browse all the conditions that are associated with Dysthymia:

Dysthymia (449 conditions)

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.