Microzide and Wellbutrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Microzide (hydrochlorothiazide) and Wellbutrin (bupropion hydrochloride). Common drug interactions include myocardial infarction among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Microzide and Wellbutrin. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Microzide?

Microzide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 994 Microzide users. Check the latest studies of Microzide.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,107 Wellbutrin users. Check the latest studies of Wellbutrin.

On Jul, 13, 2026

51 people who take Microzide and Wellbutrin together, and have interactions are studied.

Microzide and Wellbutrin drug interactions.

What are the common drug interactions of Microzide and Wellbutrin, by gender? *:

female:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pharyngolaryngeal pain
Pneumonia
Sinusitis (inflammation of sinus)
Stress incontinence (leak urine with things like coughing, sneezing or exercise)
Trigger finger
Urinary tract infection
Weight decreased
Disturbance in attention
Irritability

male:

Anaemia (lack of blood)
Dyspnoea (difficult or laboured respiration)
Blood creatine phosphokinase increased
Blood creatinine increased
Deafness
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Electrocardiogram abnormal
Fatigue (feeling of tiredness)
Femur fracture
Fluid retention (an abnormal accumulation of fluid in the blood)

What are the common drug interactions of Microzide and Wellbutrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diabetes mellitus non-insulin-dependent
Diverticulitis intestinal (digestive disease which involves the formation of pouches (diverticula) within the intestinal wall)
Eyelid function disorder
Hepatic congestion (liver congestion)
Hyperglycaemia (high blood sugar)
Hypersensitivity
Hypokalaemia (low potassium)
Obesity (having too much body fat)
Overdose
Papillary thyroid cancer

40-49:

Abdominal strangulated hernia (abdominal blood supply damaged hernia)
Influenza
Pyrexia (fever)
Rigors (an episode of shaking or exaggerated shivering)
Steatorrhoea (presence of excess fat in faeces)
Vomiting
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus insulin-dependent
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperglycaemia (high blood sugar)

50-59:

Application site erythema (redness of the skin at application site)
Application site pain
Application site rash
Delirium (wild excitement)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Discomfort
Haemangioma (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Memory impairment
Pancreatitis (inflammation of pancreas)

60+:

Anaemia (lack of blood)
Dyspnoea (difficult or laboured respiration)
Drug ineffective
Dysfunctional uterine bleeding
Emotional distress
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Influenza like illness
Leukocytosis (increased white blood cells)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 6 people, 11.76%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 11.76%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 5 people, 9.80%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 5 people, 9.80%
Prostate Cancer: 5 people, 9.80%
Pain: 5 people, 9.80%
Insomnia (sleeplessness): 5 people, 9.80%
Back Pain: 5 people, 9.80%
Multiple Myeloma (cancer of the plasma cells): 4 people, 7.84%
Menopause (end of monthly cycles in women): 4 people, 7.84%

* Approximation only. Some reports may have incomplete information.

Do you take Microzide and Wellbutrin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously