Midol and Xanax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Midol (ibuprofen) and Xanax (alprazolam). Common drug interactions include drug screen false positive among females.

The phase IV clinical study analyzes what interactions people have when they take Midol and Xanax. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Midol?

Midol has active ingredients of ibuprofen. It is often used in painful menstrual periods. eHealthMe is studying from 2,635 Midol users. Check the latest studies of Midol.

What is Xanax?

Xanax has active ingredients of alprazolam. It is often used in stress and anxiety. eHealthMe is studying from 135,347 Xanax users. Check the latest studies of Xanax.



On Jul, 10, 2026

13 people who take Midol and Xanax together, and have interactions are studied.

Midol and Xanax drug interactions.

What are the common drug interactions of Midol and Xanax, by gender? *:

female:

  1. Drug screen false positive
  2. Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
  3. Drug hypersensitivity
  4. Fall
  5. Fibromyalgia (a long-term condition which causes pain all over the body)
  6. Head injury
  7. Hypersensitivity
  8. Influenza
  9. Libido decreased (loss of interest in sex)
  10. Memory impairment

male:

n/a

What are the common drug interactions of Midol and Xanax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Hair colour changes
  2. Hair disorder
  3. Alopecia (absence of hair from areas of the body)

40-49:

  1. Drug screen false positive
  2. Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
  3. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  4. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  5. Pulmonary embolism (blockage of the main artery of the lung)
  6. Drug hypersensitivity
  7. Palpitations (feelings or sensations that your heart is pounding or racing)
  8. Paraesthesia mucosal (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect on mucosal)
  9. Seizure (abnormal excessive or synchronous neuronal activity in the brain)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Renal Cell Carcinoma (a kidney cancer): 3 people, 23.08%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 23.08%
  3. Menstrual Discomfort: 3 people, 23.08%
  4. High Blood Pressure: 3 people, 23.08%
  5. Headache (pain in head): 3 people, 23.08%
  6. Depression: 3 people, 23.08%
  7. Sinus Headache (headache caused by sinus infections): 2 people, 15.38%
  8. Hyperthyroidism (over activity of the thyroid gland): 2 people, 15.38%
  9. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 15.38%
  10. Back Pain: 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Midol and Xanax?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Midol and Xanax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Midol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Xanax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Midol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Xanax and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen and alprazolam (the active ingredients of Midol and Xanax, respectively), and Midol and Xanax (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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